Oxidative stress induced by cerebral ischemia-reperfusion and neuroprotection: Potentiality of pH-responsive radical-containing nanoparticle (RNP)

• Marushima Aiki

  Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba

• Suzuki Kensuke

  Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba Department of Neurosurgery, Dokkyo Medical University Koshigaya Hospital

• Nagasaki Yukio

  Graduate School of Pure and Applied Sciences, University of Tsukuba

• Yoshitomi Toru

  Graduate School of Pure and Applied Sciences, University of Tsukuba

• Toh Kazuko

  Graduate School of Pure and Applied Sciences, University of Tsukuba

• Tsurushima Hideo

  Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba Nanotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST)

• Hirayama Aki

  Center for Integrative Medicine, Tsukuba University of Technology

• Matsumura Akira

  Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba

Bibliographic Information

Other Title

• 脳虚血再灌流における酸化ストレス障害と脳保護療法　ｐＨ応答性ラジカル含有ナノ粒子（ｒａｄｉｃａｌ－ｃｏｎｔａｉｎｉｎｇ　ｎａｎｏｐａｒｔｉｃｌｅ：　ＲＮＰ）の可能性

Abstract

Free radicals produced by cerebral ischemia and reperfusion can extend the infarct area by the damage of ischemic penumbra, which is known as ischemia-reperfusion injury. Nitroxyl radicals such as 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) have unique anti-oxidant abilities to scavenge free radicals. However, short in vivo half-life and toxicity have limited their clinical application. In this report, the property of radical-containing nanoparticle (RNP), which was developed to overcome the limitations of nitroxyl radical, was introduced, and the molecular mechanism of it’s accumulation to ischemic brain and the scavenging effect of free radicals were demonstrated.

Journal

• Japanese Journal of Stroke

  Japanese Journal of Stroke 32 (6), 552-558, 2010

  The Japan Stroke Society

Keywords

• ischemia-reperfusion injury
• free radicals
• radical-containing nanoparticle
• neuroprotection

Details

• CRID: 1390282679613938048
• NII Article ID: 10027895635
• NII Article ID: 130004543105
• NII Book ID: AN0020186X
• DOI: 10.3995/jstroke.32.552
• ISSN: 18831923
• ISSN: 09120726
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed