Quinotrierixin Inhibited ER Stress-Induced XBP1 mRNA Splicing through Inhibition of Protein Synthesis

Quinotrierixin Inhibited ER Stress-Induced XBP1 mRNA Splicing through Inhibition of Protein Synthesis

- Yamamoto Kohta YAMAMOTO Kohta
- Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University
- Tashiro Etsu TASHIRO Etsu
- Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University
- Imoto Masaya IMOTO Masaya
- Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University

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Author(s)

- Yamamoto Kohta YAMAMOTO Kohta
- Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University
- Tashiro Etsu TASHIRO Etsu
- Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University
- Imoto Masaya IMOTO Masaya
- Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University

Abstract

Quinotrierixin was isolated from microbes as an inhibitor of ER stress-induced XBP1 mRNA splicing, but its mode of action was unclear. We found that quinotrierixin is an inhibitor of protein synthesis, and that the required dose range of quinotrierixin to inhibit ER stress-induced XBP1 mRNA splicing was similar to that to inhibit protein synthesis. Furthermore, we also found that quinotrierixin inhibited the ER stress-induced increases of unfolded protein response-related genes such as GRP78, CHOP, EDEM, ERdj4, and p58<SUP>IPK</SUP>. Thus, we showed that quinotrierixin inhibited the ER stress-induced unfolded protein response, possibly due to its inhibitory activity of protein synthesis.

Journal

Bioscience, Biotechnology, and Biochemistry

Bioscience, Biotechnology, and Biochemistry 75(2), 284-288, 2011-02-23

Japan Society for Bioscience, Biotechnology, and Agrochemistry

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Quinotrierixin Inhibited ER Stress-Induced XBP1 mRNA Splicing through Inhibition of Protein Synthesis

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