A New, Convenient Cell-Based Screening Method for Small-Molecule Glycolytic Inhibitors

• KITAGAWA Mitsuhiro

  Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University

• MISAWA Mayuko

  Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University

• OGAWA Seiichiro

  Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University

• TASHIRO Etsu

  Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University

• IMOTO Masaya

  Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University

抄録

To counteract active glycolysis in tumors, we developed a new, convenient cell-based screening system to identify an inhibitor of glycolysis. Using this system, we searched for an inhibitor in the synthetic Carbasugar library and found two candidates. It was found that both inhibited glycolysis by suppressing the glucose uptake step in tumor cells.

収録刊行物

• Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ

  Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 75 (2), 367-369, 2011

  公益社団法人 日本農芸化学会

キーワード

• inhibitor screening
• tumor glycolysis
• glucose uptake inhibitor
• carbasugar library

詳細情報

• CRID: 1390001206478730752
• NII論文ID: 10027898136
• NII書誌ID: AA10824164
• DOI: 10.1271/bbb.100693
• ISSN: 13476947
• ISSN: 09168451
• NDL書誌ID: 10993498
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10993498
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.100693
• Web Site: https://search.jamas.or.jp/link/ui/2012013063
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可