Application of Terahertz Absorption Spectroscopy to Evaluation of Aging Variation of Medicine

• KAWASE Masaya

  Nagahama Institute of Bio-science and Technology Radioisotope Research Center, Osaka University

• SAITO Tadashi

  Radioisotope Research Center, Osaka University

• OGAWA Masafumi

  Faculty of Pharmaceutical Sciences, Osaka Ohtani University

• UEJIMA Hideki

  Faculty of Pharmaceutical Sciences, Osaka Ohtani University

• HATSUDA Yasutoshi

  Faculty of Pharmaceutical Sciences, Osaka Ohtani University

• KAWANISHI Sonoyo

  Faculty of Pharmaceutical Sciences, Osaka Ohtani University

• HIROTANI Yoshihiko

  Faculty of Pharmaceutical Sciences, Osaka Ohtani University

• MYOTOKU Michiaki

  Faculty of Pharmaceutical Sciences, Osaka Ohtani University

• IKEDA Kenji

  Faculty of Pharmaceutical Sciences, Osaka Ohtani University

• KONISHI Hiroki

  Faculty of Pharmaceutical Sciences, Osaka Ohtani University

• IGA Ikumi

  Faculty of Pharmaceutical Sciences, Osaka Ohtani University

• YAMAKAWA Junji

  Graduate School of Natural Science and Technology, Okayama University

• NISHIZAWA Seizi

  Advanced Infrared Spectroscopy

• YAMAMOTO Kohji

  Research Center for Development of Far-Infrared Region, University of Fukui

• TANI Masahiko

  Research Center for Development of Far-Infrared Region, University of Fukui

抄録

The absorption spectra of three kinds of medicines both before and after the expiration date: Amlodin OD^® (5 mg), Basen OD^® (0.2 mg) and Gaster D^® (10 mg) have been measured by terahertz time domain spectroscopy (THz-TDS). All the medicines show some differences in the THz absorption spectra between medicines before and after the expiration dates. X-Ray powder diffraction (XRD) studies of all medicines suggest that the polymorph of the main effective compound is not changed before and after the expiration date. Therefore, the differences in the THz spectra between medicines before and after the expiration dates arise from aging variation of diluting agents and/or from modifications of intermolecular interaction between the effective compounds and diluting agents.

収録刊行物

• Analytical Sciences

  Analytical Sciences 27 (2), 209-, 2011

  社団法人 日本分析化学会

キーワード

• Analytical Chemistry

詳細情報

• CRID: 1390282679237110016
• NII論文ID: 10027905928
• NII書誌ID: AA10500785
• DOI: 10.2116/analsci.27.209
• COI: 1:STN:280:DC%2BC3M7pt12hsg%3D%3D
• ISSN: 13482246
• ISSN: 09106340
• NDL書誌ID: 10970736
• PubMed: 21321447
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10970736
• Web Site: https://link.springer.com/content/pdf/10.2116/analsci.27.209.pdf
• Web Site: https://link.springer.com/article/10.2116/analsci.27.209/fulltext.html
• Web Site: http://www.jstage.jst.go.jp/article/analsci/27/2/27_2_209/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2011323319
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
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