Mexiletine Reverses Oxaliplatin-Induced Neuropathic Pain in Rats
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- Egashira Nobuaki
- Department of Pharmacy, Kyushu University Hospital, Japan
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- Hirakawa Shingo
- Department of Pharmacy, Kyushu University Hospital, Japan
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- Kawashiri Takehiro
- Department of Pharmacy, Kyushu University Hospital, Japan
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- Yano Takahisa
- Department of Pharmacy, Kyushu University Hospital, Japan
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- Ikesue Hiroaki
- Department of Pharmacy, Kyushu University Hospital, Japan
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- Oishi Ryozo
- Department of Pharmacy, Kyushu University Hospital, Japan
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Abstract
Oxaliplatin is a platinum-based chemotherapy drug characterized by the development of acute and chronic peripheral neuropathies. Mexiletine, an orally available Na+-channel blocker, has widely been used in patients with chronic painful diabetic neuropathy. In the present study, we examined the effect of mexiletine on oxaliplatin-induced neuropathic pain in rats. Mexiletine (100, but not 10 and 30, mg/kg, p.o.) completely reversed both mechanical allodynia and cold hyperalgesia induced by oxaliplatin (4 mg/kg, i.p., twice a week). Lidocaine (30, but not 3 and 10, mg/kg, i.p.) also significantly relieved both pain behaviors. These results suggest that mexiletine may be effective in relieving the oxaliplatin-induced neuropathic pain clinically.
Journal
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 112 (4), 473-476, 2010
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390001205180419072
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- NII Article ID
- 10027909238
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- NII Book ID
- AA11806667
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- COI
- 1:CAS:528:DC%2BC3cXlsFWlsr8%3D
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- ISSN
- 13478648
- 13478613
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- NDL BIB ID
- 10651186
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- PubMed
- 20308797
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed