細胞内遺伝子発現制御を目指した遺伝子に対するピンポイント反応の開発

• 永次 史

  東北大学多元物質科学研究所

書誌事項

タイトル別名

• Development of the Highly Selective Reactions to Target Gene for the Control of the Gene Expression in Cells
• サイボウ ナイ イデンシ ハツゲン セイギョ オ メザシタ イデンシ ニ タイスル ピンポイント ハンノウ ノ カイハツ

抄録

The site-specific reaction with high efficiency and specificity to DNA or RNA has become of great interests, as such modification may have possibility to induce point mutation of a genetic code. The cross-linking reagents within complementary duplexes and triplexes are one of the tools for site-specific modification by forming covalently bond. However, the existing alkylating agents still need further improvement for application in either in vitro or in vivo study. Previously, we have designed a new cross-linking motif, 2-amino-6-vinylpurine(1), toward cytosine by expecting a proximity effect within the complex resembling a natural G-C pair. In this paper, we wish to describe the development of the novel cross-linking reagents based on the structure of 1.

収録刊行物

• 有機合成化学協会誌

  有機合成化学協会誌 69 (2), 108-117, 2011

  公益社団法人 有機合成化学協会

キーワード

• antisense
• antigene
• DNA
• miRNA
• cross-linking
• oligonucleotide
• sequence and base specific reaction

詳細情報

• CRID: 1390001205312912896
• NII論文ID: 10027916316
• NII書誌ID: AN0024521X
• DOI: 10.5059/yukigoseikyokaishi.69.108
• COI: 1:CAS:528:DC%2BC3MXisVaksbs%3D
• ISSN: 18836526
• ISSN: 00379980
• NDL書誌ID: 11003637
• Web Site: http://id.ndl.go.jp/bib/11003637
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I11003637
• 本文言語コード: ja
• データソース種別:
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