慢性副鼻腔炎―難治例の病態とその対応―

• 平川 勝洋

  広島大学大学院耳鼻咽喉科学・頭頸部外科学

書誌事項

タイトル別名

• Chronic Rhinosinusitis-Pathological View of Refractory Cases and Treatment Strategy-
• マンセイ フクビクウエン ナンチレイ ノ ビョウタイ ト ソノ タイオウ
• —Pathological View of Refractory Cases and Treatment Strategy—
• ―難治例の病態とその対応―

抄録

The pathophysiology of eosinophilic chronic rhinosinusitis (ECRS), a type of refractory chronic sinus inflammation accompanied by numerous infiltrations of activated eosinophils in paranasal sinus mucosa and/or nasal polyps, remains unknown, and several complex mechanisms are considered to promote eosinophil accumulation. Inflammatory entities, including cytokines—IL-5 and GM-CSF, chemokines such as eotaxin, and chemical mediators such as CysLTs are reportedly related to eosinophilic sinonasal mucosal inflammation. ECRS should be managed by focusing directly on inhibiting local eosinophil infilitration. Related surgical procedures include mechanical removal of diseased mucosal lesions and opening the bony wall septum of affected sinuses to enhance postoperative maintenance. Local and/or systemic steroids and leukotriene receptor antagonists are also recommended. Local steroid administration effectively prevents nasal polyposis relapse. Meticulous follow-up is needed in all cases because although adequate combinations of surgery and postoperative therapy keep most subjects with ECRS enjoy some relief, no treatment yet completely reliefes ECRS.<br>

収録刊行物

• 耳鼻咽喉科臨床

  耳鼻咽喉科臨床 104 (4), 239-247, 2011

  耳鼻咽喉科臨床学会

キーワード

• chronic sinusitis
• eosinophil
• leukotriene
• steroid

詳細情報

• CRID: 1390001204263507712
• NII論文ID: 10027972280
• NII書誌ID: AN00107089
• DOI: 10.5631/jibirin.104.239
• ISSN: 18844545
• ISSN: 00326313
• NDL書誌ID: 11069749
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I11069749
• Web Site: https://search.jamas.or.jp/link/ui/2011187987
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可