Dynamics of methionine biosynthesis

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Abstract

Methionine biosynthesis in plants provides the primary source of this essential amino acid. Early pioneering works characterised many of the steps involved in the methionine biosynthetic pathway and properties of the enzymes involved. They also showed that methionine biosynthesis was strictly controlled in higher plants and part of a larger, complex pathway that involves the biosynthesis of lysine, threonine and isoleucine. The adoption of the model plant <i>Arabidopsis thaliana</i> has enabled us to isolate <i>mto</i> mutants that over-accumulate soluble methionine. Through the analysis of these <i>mto</i> mutants, valuable insight has been gained into the regulation and <i>in vivo</i> dynamics of the methionine biosynthetic pathway in higher plants. Each of the three mutant <i>mto</i> loci identified to date (<i>mto1</i>, <i>mto2</i>, <i>mto3</i>) disrupt different processes within the pathway and display distinct phenotypic profiles. They have also revealed that, in addition to the common feedback controls, the pathway is subject to changing temporal and spatial regulation over the course of the plant life cycle.

Journal

  • Plant Biotechnology

    Plant Biotechnology 22(5), 379-388, 2005-12-01

    Japanese Society for Plant Cell and Molecular Biology

References:  56

Codes

  • NII Article ID (NAID)
    10028054436
  • NII NACSIS-CAT ID (NCID)
    AA11250821
  • Text Lang
    ENG
  • Article Type
    REV
  • ISSN
    13424580
  • NDL Article ID
    7742244
  • NDL Source Classification
    ZR3(科学技術--生物学--植物)
  • NDL Call No.
    Z54-J126
  • Data Source
    CJP  NDL  J-STAGE 
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