Pilocytic Astrocytoma With Histological Malignant Features Without Previous Radiation Therapy -Case Report-
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- SHIBAHARA Ichiyo
- Department of Neurosurgery, Aomori Prefectural Central Hospital
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- KAWAGUCHI Tomohiro
- Department of Neurosurgery, Aomori Prefectural Central Hospital
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- KANAMORI Masayuki
- Department of Neurosurgery, Aomori Prefectural Central Hospital
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- YONEZAWA Shingo
- Department of Neurosurgery, Aomori Prefectural Central Hospital
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- TAKAZAWA Hiroki
- Department of Neurosurgery, Aomori Prefectural Central Hospital
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- ASANO Kenichiro
- Department of Neurosurgery, Hirosaki University Graduate School of Medicine
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- OHKUMA Hiroki
- Department of Neurosurgery, Hirosaki University Graduate School of Medicine
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- KAIMORI Mitsuomi
- Department of Pathology, Aomori Prefectural Central Hospital
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- SASAKI Tatsuya
- Department of Neurosurgery, Aomori Prefectural Central Hospital
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- NISHIJIMA Michiharu
- Department of Neurosurgery, Aomori Prefectural Central Hospital
書誌事項
- タイトル別名
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- —Case Report—
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Pilocytic astrocytoma sometimes transforms to a malignant type, and previous radiation therapy is considered to be a key factor. We report a case of pilocytic astrocytoma with histological malignant features without previous radiation therapy. A 21-year-old man presented a sudden onset of severe headache. Neuroimaging had detected a cystic mass in the posterior fossa at the age of one year without therapeutic intervention. On admission, computed tomography depicted a brain tumor in the posterior fossa with cystic components, intratumoral hemorrhage, and upward herniation. Urgent surgery was performed, and histological examination revealed some features of pilocytic astrocytoma but also broad necrosis, high cellularity, and MIB-1 labeling index of more than 20%. The histological diagnosis was pilocytic astrocytoma with malignant features. This tumor had continued a benign clinical course for 20 years, but had eventually transformed to a malignant type. Therefore, pilocytic astrocytoma may undergo spontaneous malignant transformation during its natural clinical course.<br>
収録刊行物
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- Neurologia medico-chirurgica
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Neurologia medico-chirurgica 51 (2), 144-147, 2011
一般社団法人 日本脳神経外科学会
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詳細情報 詳細情報について
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- CRID
- 1390001205057710976
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- NII論文ID
- 10028105026
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- NII書誌ID
- AN00358613
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- ISSN
- 13498029
- 04708105
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- 本文言語コード
- en
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- データソース種別
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- JaLC
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- 使用不可