Effects of Low-dose Heavy Ions on the Postnatal Development of Mice and the Yield of White Spots in the Mid-ventrum and Tail-tips
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- HIROBE Tomohisa
- Radiation Effect Mechanisms Research Group, Research Center for Radiation Protection, National Institute of Radiological Sciences Graduate School of Science, Chiba University
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- EGUCHI-KASAI Kiyomi
- Radiation Effect Mechanisms Research Group, Research Center for Radiation Protection, National Institute of Radiological Sciences
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- SUGAYA Kimihiko
- Radiation Effect Mechanisms Research Group, Research Center for Radiation Protection, National Institute of Radiological Sciences
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- MURAKAMI Masahiro
- Radiation Effect Mechanisms Research Group, Research Center for Radiation Protection, National Institute of Radiological Sciences
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Effects of prenatal low-dose irradiations of heavy ions on the postnatal development of mice and of melanocytes have not been well studied. Pregnant females of C57BL/10J mice were irradiated whole-body at 9 days of gestation with a single acute dose of γ-rays, silicon (Si, 57 keV/μm), argon (Ar, 100 keV/μm) and iron (Fe, 220 keV/μm) ions. The effects were studied by scoring changes in the postnatal development of mice as well as in the pigmentation of cutaneous coats and tail-tips of their offspring 22 days after birth. The survival to day 22 decreased from the offspring exposed to 0.4 Gy of argon and iron ions and to 0.75 Gy of silicon ions. White spots were found in the mid-ventrum and tail-tips of irradiated offspring. The frequency and size of the white spots in the mid-ventrum in mice exposed to silicon, argon and iron ions were greater than those of γ-rays. Even in the low dose (0.1 Gy), γ-rays and heavy ions increased the frequency of the ventral spots. The RBE estimated by the frequency of the ventral spots was 2.3 (Si), 3.1 (Ar) and 4.5 (Fe). These results suggest that prenatal exposure to heavy ions possesses a greater effect on the postnatal development of mice as well as melanocyte development than does exposure to γ-rays.
収録刊行物
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- Journal of Radiation Research
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Journal of Radiation Research 52 (3), 278-286, 2011
Journal of Radiation Research 編集委員会
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詳細情報 詳細情報について
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- CRID
- 1390001205216055296
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- NII論文ID
- 10028111079
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- NII書誌ID
- AA00705792
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- ISSN
- 13499157
- 04493060
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- NDL書誌ID
- 11088913
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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