Regenerative medicine for insulin deficiency : creation of pancreatic islets and bioartificial pancreas

• SUMI Shoichiro

  Institute for Frontier Medical Sciences, Kyoto University

抄録

Recent advances in pancreas organogenesis have greatly improved the understanding of cell lineage from inner cell mass to fully differentiated β-cells. Based upon such knowledge, insulin-producing cells similar to β-cells to a certain extent have been generated from various cell sources including embryonic stem cells (ESCs) and induced pluripotent stem (iPS) cells, although fully differentiated cells comparable to β-cells are not yet available. The bioartificial pancreas is a therapeutic approach to enable allo- and xenotransplantation of islets without immune suppression. Among several types of bioartificial pancreases (BAPs), micro-encapsulated porcine islets are already in use in clinical trials and may, perhaps, replace islet transplantation in the near future. Some types of bioartificial pancreas such as macro-encapsulation are also useful for keeping transplanted cells enclosed in case retrieval is necessary. Therefore, early clinical applications of artificially generated β-like cells, especially those from ESCs or iPS cells, will be considered in combination with retrievable BAPs.

収録刊行物

• Journal of hepato-biliary-pancreatic sciences

  Journal of hepato-biliary-pancreatic sciences 18 (1), 6-12, 2011-01-01

  Japanese Society of Hepato-Biliary-Pancreatic Surgery and Springer

キーワード

• Diabetes mellitus
• β-cells
• Pancreas
• Insulin
• Islets of Langerhans

詳細情報

• CRID: 1573105975666054912
• NII論文ID: 10028172744
• NII書誌ID: AA12507209
• ISSN: 18686974
• Web Site: http://hdl.handle.net/2433/141997
• Web Site: https://search.jamas.or.jp/link/ui/2011287781
• 本文言語コード: en
• データソース種別:
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