Suitability of Tartrate-Resistant Acid Phosphatase Type 5b as a Screening Marker for Bone Mineral Density in Community-Dwelling Elderly Individuals Suitability of Tartrate-Resistant Acid Phosphatase Type 5b as a Screening Marker for Bone Mineral Density in Community-Dwelling Elderly Individuals

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Author(s)

    • IRIE Sumiko
    • Department of Global Health, Medicine and Welfare, Nagasaki University Graduate School of Biomedical Sciences
    • HAYASHIDA Naomi
    • Department of Global Health, Medicine and Welfare, Nagasaki University Graduate School of Biomedical Sciences
    • SHINKAWA Tetsuko
    • Department of Global Health, Medicine and Welfare, Nagasaki University Graduate School of Biomedical Sciences
    • TAIRA Yasuyuki
    • Department of Global Health, Medicine and Welfare, Nagasaki University Graduate School of Biomedical Sciences
    • SEKITANI Yui
    • Department of Global Health, Medicine and Welfare, Nagasaki University Graduate School of Biomedical Sciences
    • TERAOKA Seitaro
    • Department of Global Health, Medicine and Welfare, Nagasaki University Graduate School of Biomedical Sciences
    • HASHIGUCHI Kanami
    • Department of Global Health, Medicine and Welfare, Nagasaki University Graduate School of Biomedical Sciences
    • YOSHIDA Koji
    • Department of Global Health, Medicine and Welfare, Nagasaki University Graduate School of Biomedical Sciences
    • MORISHITA Michiko
    • Department of Global Health, Medicine and Welfare, Nagasaki University Graduate School of Biomedical Sciences
    • TAKAMURA Noboru
    • Department of Global Health, Medicine and Welfare, Nagasaki University Graduate School of Biomedical Sciences

Abstract

Osteoporosis is a common disorder in aging populations that imposes considerable health problems. Tartrate-resistant acid phosphatase type 5b (TRAP-5b) is derived from osteoclasts, and is involved in normal bone homeostasis. Recently, a novel assay system for TRAP-5b, the fragments absorbed immunocapture enzymatic assay method, has been developed. To evaluate the suitability of TRAP-5b as a screening marker for bone mineral density (BMD), we explored the correlations between serum TRAP-5b concentrations and laboratory findings, body mass index, or BMD in 462 community-dwelling elderly individuals (249 men and 213 women, age 73.4 ± 6.5 years) who participated in a regular medical screening program. By multivariate linear regression analysis adjusted for confounding factors, TRAP-5b was significantly correlated with body mass index (β = −0.005, <i>p</i> = 0.043), alkaline phosphatase, a marker for osteoid formation and calcification (β = 0.001, <i>p</i> < 0.001), and triglyceride (β = −0.097, <i>p</i> = 0.016) in men, and with body mass index (β = −0.009, <i>p</i> = 0.025), alkaline phosphatase (β = 0.001, <i>p</i> < 0.001), calcium (β = −0.059, <i>p</i> = 0.039), and bone trabecular area ratio (β = −0.47, <i>p</i> = 0.025) in women. In conclusion, the elevated serum level of TRAP-5b is independently correlated with the decreased BMD in women, but not in men. Because measurement of TRAP-5b is not affected by food intake, and blood samples can be collected at any time of the day, we suggest the suitability of serum TRAP-5b as a simple marker for the evaluation of BMD in women.

Journal

  • The Tohoku Journal of Experimental Medicine

    The Tohoku Journal of Experimental Medicine 224(2), 105-110, 2011-06-01

    Tohoku University Medical Press

References:  25

Codes

  • NII Article ID (NAID)
    10028234060
  • NII NACSIS-CAT ID (NCID)
    AA00863920
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    00408727
  • Data Source
    CJP  IR  J-STAGE 
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