Suitability of Tartrate-Resistant Acid Phosphatase Type 5b as a Screening Marker for Bone Mineral Density in Community-Dwelling Elderly Individuals
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- Irie Sumiko
- Department of Global Health, Medicine and Welfare, Nagasaki University Graduate School of Biomedical Sciences
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- Hayashida Naomi
- Department of Global Health, Medicine and Welfare, Nagasaki University Graduate School of Biomedical Sciences
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- Shinkawa Tetsuko
- Department of Global Health, Medicine and Welfare, Nagasaki University Graduate School of Biomedical Sciences
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- Taira Yasuyuki
- Department of Global Health, Medicine and Welfare, Nagasaki University Graduate School of Biomedical Sciences
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- Sekitani Yui
- Department of Global Health, Medicine and Welfare, Nagasaki University Graduate School of Biomedical Sciences
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- Teraoka Seitaro
- Department of Global Health, Medicine and Welfare, Nagasaki University Graduate School of Biomedical Sciences
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- Hashiguchi Kanami
- Department of Global Health, Medicine and Welfare, Nagasaki University Graduate School of Biomedical Sciences
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- Yoshida Koji
- Department of Global Health, Medicine and Welfare, Nagasaki University Graduate School of Biomedical Sciences
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- Morishita Michiko
- Department of Global Health, Medicine and Welfare, Nagasaki University Graduate School of Biomedical Sciences
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- Takamura Noboru
- Department of Global Health, Medicine and Welfare, Nagasaki University Graduate School of Biomedical Sciences
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抄録
Osteoporosis is a common disorder in aging populations that imposes considerable health problems. Tartrate-resistant acid phosphatase type 5b (TRAP-5b) is derived from osteoclasts, and is involved in normal bone homeostasis. Recently, a novel assay system for TRAP-5b, the fragments absorbed immunocapture enzymatic assay method, has been developed. To evaluate the suitability of TRAP-5b as a screening marker for bone mineral density (BMD), we explored the correlations between serum TRAP-5b concentrations and laboratory findings, body mass index, or BMD in 462 community-dwelling elderly individuals (249 men and 213 women, age 73.4 ± 6.5 years) who participated in a regular medical screening program. By multivariate linear regression analysis adjusted for confounding factors, TRAP-5b was significantly correlated with body mass index (β = −0.005, p = 0.043), alkaline phosphatase, a marker for osteoid formation and calcification (β = 0.001, p < 0.001), and triglyceride (β = −0.097, p = 0.016) in men, and with body mass index (β = −0.009, p = 0.025), alkaline phosphatase (β = 0.001, p < 0.001), calcium (β = −0.059, p = 0.039), and bone trabecular area ratio (β = −0.47, p = 0.025) in women. In conclusion, the elevated serum level of TRAP-5b is independently correlated with the decreased BMD in women, but not in men. Because measurement of TRAP-5b is not affected by food intake, and blood samples can be collected at any time of the day, we suggest the suitability of serum TRAP-5b as a simple marker for the evaluation of BMD in women.
収録刊行物
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- The Tohoku Journal of Experimental Medicine
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The Tohoku Journal of Experimental Medicine 224 (2), 105-110, 2011
東北ジャーナル刊行会
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詳細情報 詳細情報について
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- CRID
- 1390001204245149696
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- NII論文ID
- 10028234060
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- NII書誌ID
- AA00863920
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- ISSN
- 13493329
- 00408727
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- HANDLE
- 10069/25482
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可