ヒトにおけるブタ由来エラスチンペプチド摂取による皮膚弾力性向上作用  [in Japanese] Effect of Long-term Ingestion of Porcine Elastin Peptide on Human Skin Elasticity  [in Japanese]

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Abstract

ブタ大動脈を原料としてエラスチン加水分解ペプチド(エラスチンペプチド)を調製し,その摂取がヒトの皮膚弾力性にもたらす影響について検討した.はじめに,エラスチンペプチド経口摂取後のヒト血液中のアミノ酸濃度の変化を観察した.成人男性5名を被験者として,12時間絶食後にエラスチンペプチドを摂取させた.その結果,エラスチンペプチド経口摂取後に血中の総アミノ酸量が増加し,増加したアミノ酸の組成は,摂取したエラスチンペプチドのアミノ酸組成に類似していた.また,ハイドロキシプロリンおよびアルギニンがそれぞれペプチド態として血中に検出され,エラスチンペプチドの少なくとも一部はペプチド態として血中に移行していると考えられた.次に,39名の中高齢者を3群にわけ1日量0, 100, 200mgのエラスチンペプチドを8週間継続摂取させ皮膚弾力性を測定した.100mg, 200mg摂取群において摂取開始8週目に摂取前と比較して有意に皮膚弾力性が上昇した.またその変化率は0mgと比較して200mg群で有意に高値を示した.以上より,エラスチンペプチドの経口摂取はヒトの皮膚弾力性を向上させることが示唆された.

The effect of oral administration of elastin peptide (hydrolysate of elastin from porcine aorta) on human skin elasticity was studied. First, five healthy volunteers were administered elastin peptide after fasting for 12h. A significant increase in total amino acid concentration in blood was observed. The composition of increased amino acids in blood was similar to the amino acid composition of the elastin peptide. In addition, the concentrations of peptide forms of hydroxyproline and arginine significantly increased in blood. These results suggest that a portion of the administered elastin peptide migrates into blood in peptide form. Second, thirty-nine middle-aged volunteers were divided into three groups and administered 0, 100, or 200mg/day of elastin peptide for 8 weeks. Significant increases in skin elasticity were observed in the 100and 200-mg groups after 8 weeks. Increase in skin elasticity of the 200-mg group was significantly higher than that in the 0-mg group. These results suggest that ingestion of elastin peptide increases skin elasticity.

Journal

  • Nippon Shokuhin Kagaku Kogaku Kaishi

    Nippon Shokuhin Kagaku Kogaku Kaishi 58(4), 159-163, 2011-04-15

    Japanese Society for Food Science and Technology

References:  18

Codes

  • NII Article ID (NAID)
    10028259802
  • NII NACSIS-CAT ID (NCID)
    AN10467499
  • Text Lang
    JPN
  • Article Type
    ART
  • ISSN
    1341027X
  • NDL Article ID
    11036070
  • NDL Source Classification
    ZP34(科学技術--食品工学・工業)
  • NDL Call No.
    Z17-126
  • Data Source
    CJP  NDL  IR  J-STAGE 
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