Soybean β-conglycinin bromelain hydrolysate stimulates cholecystokinin secretion by enteroendocrine STC-1 cells to suppress the appetite of rats under meal-feeding conditions

• SUFIAN Md. Kaosar Niaz Bin

  Research Faculty of Agriculture, Hokkaido University Department of Animal Breeding and Genetics, Faculty of Animal Science and Veterinary Medicine, Patuakhali Science and Technology University

• HIRA Tohru

  Research Faculty of Agriculture, Hokkaido University

• NAKAMORI Toshihiro

  Fuji Oil Co., Ltd.

• FURUTA Hitoshi

  Fuji Oil Co., Ltd.

• ASANO Kozo

  Research Faculty of Agriculture, Hokkaido University

• HARA Hiroshi

  Research Faculty of Agriculture, Hokkaido University

書誌事項

タイトル別名

• Soybean .BETA.-Conglycinin Bromelain Hydrolysate Stimulates Cholecystokinin Secretion by Enteroendocrine STC-1 Cells to Suppress the Appetite of Rats under Meal-Feeding Conditions
• Soybean v conglycinin bromelain hydrolysate stimulates cholecystokinin secretion by enteroendocrine STC 1 cells to suppress the appetite of rats under meal feeding conditions

抄録

A peptic digest of soybean β-conglycinin (BconP) suppresses the appetite in rats through cholecystokinin (CCK) secretion by enteroendocrine cells. We investigate in this study more appetite-suppressing hydrolysates. β-Conglycinin hydrolyzed with food-processing proteases thermolysin (BconT), bromelain (BconB), chymotrypsin, protease S, and protease M was examined for CCK-secreting activity in a CCK-producing cell line for comparison with BconP. The potent CCK-releasing hydrolysates were then tested for their suppression of the food intake by rats. BconB, BconT, and BconP stimulated high CCK secretion, with the highest by BconB. Orogastric preloading by BconB, but not by BconT, suppressed the 60-min food intake. A meal-feeding trial twice a day in the morning (a.m.) and evening (p.m.) for 10 d showed that BconB preloading before every meal attenuated the p.m. meal size, but not that a.m., resulting in an overall reduction of the daily meal size. These results demonstrate that the bromelain hydrolysate of β-conglycinin having potent CCK-releasing activity suppressed the appetite of rats under meal-feeding conditions.

収録刊行物

• Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ

  Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 75 (5), 848-853, 2011

  公益社団法人 日本農芸化学会

キーワード

• appetite
• cholecystokinin
• enteroendocrine STC-1 cell
• rat
• soybean β-conglycinin

詳細情報

• CRID: 1390001206478534656
• NII論文ID: 10028272318
• NII書誌ID: AA10824164
• DOI: 10.1271/bbb.100765
• ISSN: 13476947
• ISSN: 09168451
• NDL書誌ID: 11088581
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I11088581
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.100765
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可