Estrogen Increases c-Fos Expression in the Paraventricular Nucleus along with its Anorexic Effect in Developing Rats
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- CHI Jing Hua
- Department of Integrative Physiology, Faculty of Medical Sciences, University of Fukui
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- NARITA Kazumi
- Department of Integrative Physiology, Faculty of Medical Sciences, University of Fukui
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- ICHIMARU Toru
- Department of Integrative Physiology, Faculty of Medical Sciences, University of Fukui
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- MURATA Takuya
- Department of Integrative Physiology, Faculty of Medical Sciences, University of Fukui
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Estrogen inhibits food intake in cycling females in a variety of species. To determine how the development of the anorexic system by estrogen is regulated, rat pups at four developmental stages, postnatal day 11 (P11)-13, P20-22, P25-27 and P29-31, and adult ovariectomized (OVX) rats received a daily subcutaneous injection of 20 μg/kg of estradiol benzoate (EB) or vehicle for three days. Food intake, body weight gain and immunohistochemical c-Fos expression in the brain were measured after each injection. EB treatment decreased both food intake and body weight gain from P27 onwards and significantly increased c-Fos expression in the parvocellular division of the paraventricular nucleus of the hypothalamus (pPVN), which is coincident with its anorexic effect in developing rats. The pattern of EB-induced c-Fos activation in other feeding-related nuclei did not coincide with its anorexic effect in developing pups. However, in adult OVX rats, EB treatment increased c-Fos expression in the nucleus tractus solitarius (NTS), the central nucleus of the amygdala (CeA), and, to a lesser degree, the ventromedial nucleus of the hypothalamus (VMH). These results suggested that the pPVN is an essential site in the brain for controlling the anorexic effect of estrogen and that the feeding system of rat begins to respond to estrogen before the onset of puberty (P25-28).<br>
収録刊行物
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- Journal of Reproduction and Development
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Journal of Reproduction and Development 57 (3), 365-372, 2011
公益社団法人 日本繁殖生物学会
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詳細情報 詳細情報について
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- CRID
- 1390282681314618368
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- NII論文ID
- 10029050554
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- NII書誌ID
- AA10936678
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- ISSN
- 13484400
- 09168818
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- NDL書誌ID
- 11131902
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可