Elucidation of tumor suppressive function of miR-145, miR-133a and miR-133b and identification of their target genes in head and neck squamous cell carcinoma

• Hanazawa Toyoyuki

  Department of Otorhinolaryngology/Head and Neck Surgery, Graduate School of Medicine, Chiba University

• Kikkawa Naoko

  Department of Otorhinolaryngology/Head and Neck Surgery, Graduate School of Medicine, Chiba University Department of Functional Genomics, Graduate School of Medicine, Chiba University

• Nohata Nijiro

  Department of Otorhinolaryngology/Head and Neck Surgery, Graduate School of Medicine, Chiba University Department of Functional Genomics, Graduate School of Medicine, Chiba University

• Katada Koji

  Department of Otorhinolaryngology/Head and Neck Surgery, Graduate School of Medicine, Chiba University

• Mutallip Muradil

  Department of Otorhinolaryngology/Head and Neck Surgery, Graduate School of Medicine, Chiba University

• Suzuki Homare

  Department of Otorhinolaryngology/Head and Neck Surgery, Graduate School of Medicine, Chiba University

• Sasaki Keita

  Department of Otorhinolaryngology/Head and Neck Surgery, Graduate School of Medicine, Chiba University

• Chazono Hideaki

  Department of Otorhinolaryngology/Head and Neck Surgery, Graduate School of Medicine, Chiba University

• Horiguchi Shigetoshi

  Department of Otorhinolaryngology/Head and Neck Surgery, Graduate School of Medicine, Chiba University

• Okamoto Yoshitaka

  Department of Otorhinolaryngology/Head and Neck Surgery, Graduate School of Medicine, Chiba University

• Seki Naohiko

  Department of Functional Genomics, Graduate School of Medicine, Chiba University

Bibliographic Information

Other Title

• マイクロＲＮＡ（ｍｉＲ－１４５，ｍｉＲ－１３３ａ・ｂ）の頭頸部扁平上皮癌における増殖・浸潤抑制機能と標的遺伝子の同定

Abstract

MicroRNAs (miRNAs) are abundant classes of small non-coding RNAs of about 19-21 nucleotides in length, which regulate gene expression primarily at the posttranscriptional level. Growing evidence suggests that miRNAs are aberrantly expressed in many human cancers, and that they play significant roles in carcinogenesis and cancer progression. Recently, we identified a subset of down-regulated miRNAs (miR-145, miR-133a and miR-133b) in various cancer signatures. In this study, we elucidate the tumor suppressive functions of miR-145, miR-133a and miR-133b and identify their target genes in head and neck squamous cell carcinoma (HNSCC). These findings may provide new insight into the potential mechanisms of HNSCC carcinogenesis.

Journal

• Toukeibu Gan

  Toukeibu Gan 36 (1), 1-8, 2010

  Japan Society for Head and Neck Cancer

Keywords

• microRNA
• Head and neck squamous cell carcinoma
• <i>miR-145</i>
• <i>miR-133a</i>
• <i>miR-133b</i>
• FSCN1

Details

• CRID: 1390282680198742656
• NII Article ID: 10029079202
• NII Book ID: AA11985555
• DOI: 10.5981/jjhnc.36.1
• ISSN: 18818382
• ISSN: 13495747
• Web Site: https://search.jamas.or.jp/link/ui/2010195461
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed