Prevalence and prognosis of human papillomavirus in oropharyngeal cancer

• Mizumachi Takatsugu

  Department of Otolaryngology, Head and Neck Surgery, Hokkaido University Graduate School of Medicine

• Kano Satoshi

  Department of Otolaryngology, Head and Neck Surgery, Hokkaido University Graduate School of Medicine

• Hara Toshihiro

  Department of Otolaryngology, Head and Neck Surgery, Hokkaido University Graduate School of Medicine

• Suzuki Fumiyuki

  Department of Otolaryngology, Head and Neck Surgery, Hokkaido University Graduate School of Medicine

• Suzuki Seigo

  Department of Otolaryngology, Head and Neck Surgery, Hokkaido University Graduate School of Medicine

• Homma Akihiro

  Department of Otolaryngology, Head and Neck Surgery, Hokkaido University Graduate School of Medicine

• Oridate Nobuhiko

  Department of Otolaryngology, Head and Neck Surgery, Hokkaido University Graduate School of Medicine

• Fukuda Satoshi

  Department of Otolaryngology, Head and Neck Surgery, Hokkaido University Graduate School of Medicine

Bibliographic Information

Other Title

• 中咽頭扁平上皮癌におけるＨＰＶ感染と治療成績の検討

Abstract

We analyzed the presence of HPV from 53 patients diagnosed with oropharyngeal squamous cell carcinoma. In total 14/53 (26%) were HPV-positive. In 14 HPV-positive patients, 12 patients (86%) were HPV-16-positive, 1 patient was HPV-18-positive, and 1 patient was HPV-58-positive. HPV-positive patients had significantly better disease-specific survival rates than HPV-negative patients. Compared with patients with HPV-negative tumors, patients with HPV-positive tumors had higher response rates after chemoradiation treatment. For patients with HNSCC of the oropharynx, tumor HPV status is strongly associated with chemoradiation response and survival.

Journal

• Toukeibu Gan

  Toukeibu Gan 36 (4), 498-501, 2010

  Japan Society for Head and Neck Cancer

Keywords

• Oropharyngeal cancer
• Head and neck cancer
• Human papillomavirus
• Chemoradiation

Details

• CRID: 1390282680199860224
• NII Article ID: 10029080133
• NII Article ID: 130004510091
• NII Book ID: AA11985555
• DOI: 10.5981/jjhnc.36.498
• ISSN: 18818382
• ISSN: 13495747
• Web Site: https://search.jamas.or.jp/link/ui/2011111517
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed