Clinical Analysis of Malignant Submandibular Tumor

• Kitao Kyoko

  Department of Otolaryngology-Head & Neck Surgery, Hokkaido University Graduate School of Medicine

• Homma Akihiro

  Department of Otolaryngology-Head & Neck Surgery, Hokkaido University Graduate School of Medicine

• Oridate Nobuhiko

  Department of Otolaryngology-Head & Neck Surgery, Hokkaido University Graduate School of Medicine

• Suzuki Seigo

  Department of Otolaryngology-Head & Neck Surgery, Hokkaido University Graduate School of Medicine

• Suzuki Fumiyuki

  Department of Otolaryngology-Head & Neck Surgery, Hokkaido University Graduate School of Medicine

• Hara Toshihiro

  Department of Otolaryngology-Head & Neck Surgery, Hokkaido University Graduate School of Medicine

• Kano Satoshi

  Department of Otolaryngology-Head & Neck Surgery, Hokkaido University Graduate School of Medicine

• Mizumachi Takatsugu

  Department of Otolaryngology-Head & Neck Surgery, Hokkaido University Graduate School of Medicine

• Taki Shigenari

  Department of Otolaryngology-Head & Neck Surgery, Hokkaido University Graduate School of Medicine

• Inamura Naoya

  Department of Otolaryngology-Head & Neck Surgery, Hokkaido University Graduate School of Medicine

• Fukuda Satoshi

  Department of Otolaryngology-Head & Neck Surgery, Hokkaido University Graduate School of Medicine

Bibliographic Information

Other Title

• 顎下腺悪性腫瘍１次症例の検討
• ガッカセン アクセイ シュヨウ 1ジ ショウレイ ノ ケントウ

Abstract

The 14 cases of malignant submandibular tumor whose treatment outcome we analyzed between 1989 and 2008 uncluded 5 of adenoid cystic carcinoma, 3 of squamous cell carcinoma, 2 each of mucoepidermoid carcinoma, and carcinoma ex pleomorphic adenoma, and 1 each of carcinosarcoma and large-cell carcinoma. One subject was diagnosed with T1, 7 with T2, 4 with T3, and 2 with T4. Lymph node involvement occurred in 5, -1 with N1 and 4 with N2. None had distant metastasis on the first visit.<br>Seven were treated by surgery alone, 3 by surgery followed by radiotherapy, 2 by surgery followed by radio-and chemotherapy, and 1 by optimized supportive care. The surgical resection area was decided by tumor extension. Neck dissection was done in 9. Overall 5-year survival for all cases based on the Kaplan-Meier method was 57%. All with carcinoma ex pleomorphic adenoma, carcinosarcoma, or large-cell carcinoma remain alive. For those with adenoid cystic carcinoma 5-year survival is 80%, with mucoepidermoid carcinoma 50%, with squamous cell carcinoma 0%, and with carcinosarcoma 0%, respectively. The 5-year survival for stage I subjects was 100%, for stage II 83%, for stage III 50%, and for stage IV 0%.<br>Surgical resection and postoperative radiotherapy were done in cases of minimal extraglandular extension or microscopically positive margins, with satisfactory results. Treatment efficacy for high-grade and advanced stage, however, requires more inprovement.

Journal

• Nippon Jibiinkoka Gakkai Kaiho

  Nippon Jibiinkoka Gakkai Kaiho 114 (3), 126-132, 2011

  Japanese Society of Otorhinolaryngology-Head and neck surgery

Keywords

• submandibular gland
• malignant tumor
• pathology
• stage

Details

• CRID: 1390282679988948096
• NII Article ID: 10029089793
• NII Book ID: AN00191551
• DOI: 10.3950/jibiinkoka.114.126
• COI: 1:STN:280:DC%2BC3MvmtFWgsw%3D%3D
• ISSN: 18830854
• ISSN: 00306622
• NDL BIB ID: 11055591
• PubMed: 21516710
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I11055591
• Web Site: https://search.jamas.or.jp/link/ui/2011168664
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed