GASTROINTESTINAL HEMORRHAGE DUE TO SORAFENIB IN TWO PATIENTS WITH ADVANCED HEPATOCELLULAR CARCINOMA

• WATANABE Takao

  Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine.

• HIASA Yoichi

  Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine.

• HIROOKA Masashi

  Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine.

• KISAKA Yoshiyasu

  Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine.

• FURUKAWA Shinya

  Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine.

• ABE Masanori

  Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine.

• MURAKAMI Hidehiro

  Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine.

• IKEDA Yoshio

  Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine.

• MATSUURA Bunzo

  Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine.

• ONJI Morikazu

  Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine.

Bibliographic Information

Other Title

• ソラフェニブにより消化管出血を発症した進行肝細胞癌の2例

Abstract

Two patients who had gastrointestinal hemorrhage due to Sorafenib are presented. In case 1, bloody stools occurred within 1 week after the Sorafenib treatment. The endoscopic findings revealed edematous and reddish changes in the duodenal mucosa. In case 2, bloody stools occurred 1 month after the Sorafenib treatment. Colonoscopic findings indicated similar mucosal change in the colon. The hemorrhagic points were difficult to detect in both cases. However, a quick improvement in the bloody stools after stopping Sorafenib intake suggested that the gastrointestinal hemorrhage was associated with Sorafenib treatment. The endoscopic mucosal findings in both cases would probably be characteristic of patients with gastrointestinal hemorrhage due to Sorafenib.

Journal

• GASTROENTEROLOGICAL ENDOSCOPY

  GASTROENTEROLOGICAL ENDOSCOPY 53 (6), 1626-1633, 2011

  Japan Gastroenterological Endoscopy Society

Keywords

• ソラフェニブ
• 消化管出血
• 門脈圧亢進症性腸症
• 内視鏡所見
• 肝細胞癌

Details

• CRID: 1390001204218192512
• NII Article ID: 10029092728
• NII Book ID: AN00192102
• DOI: 10.11280/gee.53.1626
• ISSN: 18845738
• ISSN: 03871207
• Web Site: https://search.jamas.or.jp/link/ui/2011281818
• Text Lang: ja
• Data Source:
  • JaLC
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed