Biological Safety of Nasal Thallium-201 Administration: A Preclinical Study for Olfacto-scintigraphy

• WASHIYAMA Kohshin

  Department of Quantum Medical Technology, Graduate School of Medical Science, Kanazawa University

• SHIGA Hideaki

  Department of Quantum Medical Technology, Graduate School of Medical Science, Kanazawa University Department of Otorhinolaryngology-Head and Neck Surgery, Kanazawa Medical University

• HIROTA Kyoko

  Department of Otorhinolaryngology-Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University

• TSUCHIDA Asuka

  Department of Otorhinolaryngology-Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University

• YAMAMOTO Junpei

  Department of Otorhinolaryngology-Head and Neck Surgery, Kanazawa Medical University

• YAGI Sayaka

  Department of Otorhinolaryngology-Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University

• YOSHIZAKI Tomokazu

  Department of Otorhinolaryngology-Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University

• FURUKAWA Mitsuru

  Kanazawa University

• AMANO Ryohei

  Department of Quantum Medical Technology, Graduate School of Medical Science, Kanazawa University

• MIWA Takaki

  Department of Otorhinolaryngology-Head and Neck Surgery, Kanazawa Medical University

抄録

Nasal administration of thallium-201 (²⁰¹Tl) has previously been shown to be useful for the assessment of olfactory nerve connectivity in vivo. We assessed the biological effects of nasal ²⁰¹Tl administration in mice to determine its safety before conducting clinical trials on humans. ²⁰¹Tl uptake was evaluated in normal mice (n = 5) in vivo by using a high-resolution gamma camera and radiography 15 min, 1, 2 and 9 d after administration of ²⁰¹TlCl to the right side of the nasal cavity (10 μl ²⁰¹TlCl per nostril, 74 MBq/ml). Murine olfactory epithelial thickness (n = 5) was measured 9 d following nasal administration of ²⁰¹TlCl. We assessed the odor detection ability of normal mice (n = 8) following nasal administration of ²⁰¹TlCl to both sides of the nasal cavity, by observing cycloheximide solution avoidance behavior. We subsequently administrated ²⁰¹TlCl (n = 4) or saline (n = 4) to both nostrils to assess the odor detection ability of mice following bilateral olfactory nerve transection. ²⁰¹Tl uptake by the nasal cavity decreased immediately following nasal administration of ²⁰¹Tl in normal mice. Nasal administration of ²⁰¹Tl did not affect the olfactory epithelial thickness or the odor detection ability of normal mice. Recovery of odor detection ability following olfactory nerve transection was not significantly different between mice nasally administered with ²⁰¹Tl, and mice administered with saline. Thus, nasal administration of ²⁰¹Tl for the diagnosis of traumatic olfactory impairment did not produce harmful biological effects in vivo.

収録刊行物

• Journal of Radiation Research

  Journal of Radiation Research 52 (4), 450-455, 2011

  Journal of Radiation Research 編集委員会

キーワード

• Thallium-201
• Nasal administration
• Biological safety
• Preclinical study

詳細情報

• CRID: 1390282680191882496
• NII論文ID: 10029122142
• NII書誌ID: AA00705792
• DOI: 10.1269/jrr.10153
• DOI: 10.24517/00013484
• COI: 1:STN:280:DC%2BC3MfitlyktA%3D%3D
• ISSN: 13499157
• ISSN: 04493060
• NDL書誌ID: 11164079
• PubMed: 21905306
• Web Site: http://hdl.handle.net/2297/29212
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I11164079
• Web Site: http://academic.oup.com/jrr/article-pdf/52/4/450/3595384/jrr-52-450.pdf
• Web Site: https://search.jamas.or.jp/link/ui/2012169371
• 本文言語コード: en
• データソース種別:
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  • IRDB
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
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