Pathophysiological Roles of NADPH Oxidase/Nox Family Proteins in the Vascular System : Review and Perspective

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Author(s)

    • AGO Tetsuro
    • Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
    • KURODA Junya
    • Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
    • KAMOUCHI Masahiro
    • Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
    • SADOSHIMA Junichi
    • Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School
    • KITAZONO Takanari
    • Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University

Abstract

It has been established that oxidative stress plays a crucial role in the development and progression of vascular diseases. Besides the mitochondria, the NADPH oxidase/Nox family proteins are now thought to be important origins of the reactive oxygen species that underlie various vascular disease states, such as hypertension, atherosclerosis, angiogenesis, and ischemia/reperfusion injury. This review summarizes the basis of vascular Nox proteins and discusses their pathophysiological roles in the vascular system. (<i>Circ J</i> 2011; <b>75:</b> 1791-1800)<br>

Journal

  • Circulation Journal

    Circulation Journal 75(8), 1791-1800, 2011-07-25

    The Japanese Circulation Society

References:  100

Cited by:  9

Codes

  • NII Article ID (NAID)
    10029127248
  • NII NACSIS-CAT ID (NCID)
    AA11591968
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    13469843
  • Data Source
    CJP  CJPref  J-STAGE 
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