Impact of the Low- to High-Density Lipoprotein Cholesterol Ratio on Composition of Angiographically Ambiguous Left Main Coronary Artery Plaque

• Kurebayashi Nobutake

  Department of Cardiology, Nagoya University Graduate School of Medicine

• Yoshikawa Daiji

  Department of Cardiology, Nagoya University Graduate School of Medicine

• Ishii Hideki

  Department of Cardiology, Nagoya University Graduate School of Medicine

• Sato Bummei

  Department of Cardiology, Nagoya University Graduate School of Medicine

• Ando Hirohiko

  Department of Cardiology, Nagoya University Graduate School of Medicine

• Okada Takuya

  Department of Cardiology, Nagoya University Graduate School of Medicine

• Hayakawa Seiichi

  Department of Cardiology, Nagoya University Graduate School of Medicine

• Okumura Naoki

  Department of Cardiology, Nagoya University Graduate School of Medicine

• Isobe Satoshi

  Department of Cardiology, Nagoya University Graduate School of Medicine

• Takeshita Kyosuke

  Department of Cardiology, Nagoya University Graduate School of Medicine

• Hayashi Mutsuharu

  Department of Cardiology, Nagoya University Graduate School of Medicine

• Uetani Tadayuki

  Department of Cardiology, Chubu Rosai Hospital

• Amano Tetsuya

  Department of Cardiology, Chubu Rosai Hospital

• Murohara Toyoaki

  Department of Cardiology, Nagoya University Graduate School of Medicine

抄録

Background: A high low-density lipoprotein cholesterol (LDL-C) to a high-density lipoprotein cholesterol (HDL-C) ratio is associated with cardiac events, while the left main coronary artery (LMCA) is considered to be an important target of atherosclerotic plaque accumulation. This aim of the present study was to investigate the relationship between a LDL-C/HDL-C ratio and the characteristics of tissue components of LMCA plaque. Methods and Results: One-hundred-twenty consecutive patients with stable angina pectoris who received chronic statin treatment underwent percutaneous coronary intervention for the left coronary artery. We prospectively performed integrated backscatter (IB) intravascular ultrasound (IVUS) to their LMCAs and evaluated the tissue characteristics. According to the median value of their LDL-C/HDL-C ratios (2.4), they were divided into 2 groups [high LDL-C/HDL-C ratio (>2.4) (n=60) or low LDL-C/HDL-C ratio (≤2.4) (n=60)]. There was no significant difference in the data analyzed using conventional IVUS between the 2 groups. In the IB-IVUS analysis, patients with a high LDL-C/HDL-C ratio had a larger lipid volume and a smaller fibrous volume compared to patients with a low LDL-C/HDL-C ratio (52±10% vs. 48±10%, P=0.014 and 45±9% vs. 50±10%, P=0.010). Conclusions: A high LDL-C/HDL-C ratio was associated with a high percentage of lipid volume and a low percentage of fibrous volume in LMCA lesions. Our findings might well suggest the increased risk of cardiovascular events in patients with a high LDL-C/HDL-C ratio. (Circ J 2011; 75: 1960-1967)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 75 (8), 1960-1967, 2011

  一般社団法人 日本循環器学会

キーワード

• Integrated backscatter intravascular ultrasound
• Left main coronary artery
• Low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio

詳細情報

• CRID: 1390001205102179968
• NII論文ID: 10029128155
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-11-0019
• COI: 1:CAS:528:DC%2BC3MXhtFSlsLbF
• ISSN: 13474820
• ISSN: 13469843
• PubMed: 21646726
• Web Site: http://www.jstage.jst.go.jp/article/circj/75/8/75_CJ-11-0019/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2012074391
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可