Serum Concentration of Heart-Type Fatty Acid-Binding Protein in Children and Adolescents With Congenital Heart Disease

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Abstract

Background: Serum heart-type fatty acid-binding protein (H-FABP) is widely applied as a marker of cardiac myocyte injury. Recently, it has been reported that levels of H-FABP are elevated in adult patients with chronic heart failure and thus provide useful prognostic information. The aim of the present study was to examine the relationships between serum H-FABP levels and pathophysiological characteristics in children and adolescents with congenital heart disease (CHD). Methods and Results: Serum H-FABP levels were preoperatively and postoperatively measured in 238 consecutive patients with CHD aged 1-31 years. The relationships between H-FABP levels and severity of heart failure, circulatory status and laboratory data were cross-sectionally analyzed. Multivariate regression analysis indicated that serum H-FABP levels are independently affected by age, New York Heart Association functional class, creatine kinase MB, creatinine and arterial oxygen saturation (standard regression coefficients, -0.378, 0.237, 0.422, 0.615, and -0.210, respectively). Neither left ventricular ejection fraction nor B-type natriuretic peptide correlated with H-FABP levels. Conclusions: H-FABP could serve as a new monitoring tool to provide information that will guide the optimal therapy and management of CHD patients. (Circ J 2011; 75: 1992-1997)<br>

Journal

  • Circulation Journal

    Circulation Journal 75 (8), 1992-1997, 2011

    The Japanese Circulation Society

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