尿管結石による疝痛発作時の芍薬甘草湯の効果  [in Japanese] The Effect of Shakuyakukanzoto for Renal Colic  [in Japanese]

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Abstract

尿管結石の疝痛発作に対して芍薬甘草湯を投与し,その臨床的有用性を非ステロイド性消炎鎮痛剤(NSAIDs)と比較検討した。対象は尿管結石患者25名で,11名に対し芍薬甘草湯5.0gを内服させ,コントロール群として,14名にNSAIDsを内服させた。内服時,内服後15分,30分,60分にNRS(numerical rating scale)を用いて比較検討した。NRSは0点を全く痛みなし,10点を最も強い痛みとした。結果は芍薬甘草湯内服群では内服時NRSは6.7 ± 2.3点で,内服後15分で3.4 ± 3.5点と有意に軽減した。NSAIDs内服群では内服時8.3 ± 1.8点で,内服後15分では7.0 ± 1.9点と有意な鎮痛効果は認めたが,鎮痛効果は芍薬甘草湯の方が有意に優れていた。その他の時点においても同様の結果で,芍薬甘草湯は尿管結石の疝痛発作に対して即効性があり,NSAIDsよりも有意に鎮痛効果を認めた。

Aim:Shakuyakukanzoto is a Japanese herbal medicine that is known to be useful for the treatment of urinary stone pain. In this study, we investigated the effects of shakuyakukanzoto for acute renal colic.<br>Methods:Twenty-five patients were enrolled in this study. Eleven patients took 5.0 g of shakuyakukanzoto powder, and 14 control patients took non-steroidal anti-inflammatory drugs (NSAIDs) for their acute renal colic. The effects were evaluated before and 15, 30, and 60 minutes after treatment with a numerical rating scale (NRS). We defined scale point zero as not having pain, and scale point ten as having the strongest pain.<br>Results:Mean NRS scores improved from 6.7 ± 2.3 to 3.4 ± 3.5 after 15 minutes (shakuyakukanzoto group), and from 8.3 ± 1.8 to 7.0 ± 1.9 after 15 minutes (control group). NRS scores were improved immediately and significantly in both groups. The NRS score of shakuyakukanzoto group was significantly lower than that of control group at the any time after treatment. No side effects were observed in this study.<br>Conclusion : Shakuyakukanzoto has an immediate effect, and it is more effective than NSAIDs. Shakuyakukanzoto was a useful treatment for acute renal colic.

Journal

  • Kampo Medicine

    Kampo Medicine 62(3), 359-362, 2011-05-20

    The Japan Society for Oriental Medicine

References:  11

Codes

  • NII Article ID (NAID)
    10029129614
  • NII NACSIS-CAT ID (NCID)
    AN00015774
  • Text Lang
    JPN
  • Article Type
    NOT
  • ISSN
    02874857
  • NDL Article ID
    11156579
  • NDL Source Classification
    ZS47(科学技術--医学--治療医学・看護学・漢方医学)
  • NDL Call No.
    Z19-246
  • Data Source
    CJP  NDL  J-STAGE 
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