The Cutting Edge of Mechanical Unfolding Research: What We Learn from Protein Pulling Studies

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  • TANIGUCHI Yukinori
    School of Materials Science, Japan Advanced Institute of Science and Technology
  • KOBAYASHI Akiko
    School of Materials Science, Japan Advanced Institute of Science and Technology
  • KAWAKAMI Masaru
    School of Materials Science, Japan Advanced Institute of Science and Technology

Bibliographic Information

Other Title
  • メカニカルアンフォールディング研究の最前線‐タンパク質を引っ張ってみてわかること‐
  • メカニカルアンフォールディング研究の最前線--タンパク質を引っ張ってみてわかること
  • メカニカルアンフォールディング ケンキュウ ノ サイゼンセン タンパクシツ オ ヒッパッテ ミテワカル コト

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Abstract

Using atomic force microscopy technique, it is capable of picking up a single protein molecule to apply a mechanical force. This technique, called “force spectroscopy”, provides unique information about the intermediates and the free energy landscape of the mechanical unfolding of proteins. In this review we introduce recent studies that answer some fundamental questions: “Is the mechanical resistance of protein isotropic?”, “What is the structure of the transition state in the mechanical unfolding like?” and “Is the mechanical unfolding related to biological functions?”.<br>

Journal

  • Seibutsu Butsuri

    Seibutsu Butsuri 51 (4), 168-173, 2011

    The Biophysical Society of Japan General Incorporated Association

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