Study on the anti-coagulable mechanisms of T-NCVC coating

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  • 抗血栓性表面処理Ｔ‐ＮＣＶＣコーティングの抗凝血作用機序に関する研究

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Abstract

We were able to develop the anti-thrombogenic surface coating technology “T-NCVC coating” which allows for the continuation of long-term anticoagulation effects. In this study, we focused on the dynamics of blood protein adsorption to the coated surface as well as cell adhesion using cultured fibroblasts and analyzed the antithrombotic mechanisms of T-NCVC coating. As the characteristics of our coating technology with regard to blood, our study showed the inhibitory actions against cell adhesion not affected by proteins adhering and the presence of other plasma proteins on the coated surface. On the other hand, our technology was identified that it has membrane-toxicity against blood cells indicated by the increase in neutrophil activation and hemolytic rate. These actions between the blood and our coating technology were suggested to be one of the causes for the long-term effects of this coating technology. These antithrombotic mechanisms were different from those that had been previously proposed and are important observations in clarifying the process of thrombosis formation on artificial materials coming in contact with blood.

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