An Investigation of a Computational Analysis Method for Blood Flow and Blood-Gas Transfer using a Micro Passage with Oxygenators Hollow Fiber Membranes

• Katagiri Nobumasa

  Dept, of Artificial Organs, National Cardiovascular Center Research Institute.

• Funakubo Akio

  Dept, of Electronic Computational Engineering, Tokyo Denki University.

• Tsukiya Tomonori

  Dept, of Artificial Organs, National Cardiovascular Center Research Institute.

• Tatsumi Eisuke

  Dept, of Artificial Organs, National Cardiovascular Center Research Institute.

• Taenaka Yoshiyuki

  Dept, of Artificial Organs, National Cardiovascular Center Research Institute.

• Fukui Yasuhiro

  Dept, of Electronic Computational Engineering, Tokyo Denki University.

Bibliographic Information

Other Title

• 人工肺用中空糸膜間の微小流路における血流速と血液ガス移動の数値解析手法に関する検討

Abstract

Computational analysis has been becoming useful approch to improving design of blood passages in membrane oxgenators. However,most of computationalanalysis methods focused on fluid dynamics in the blood layer to take into account a macro design of a blood passage. We focused on the gas transfer behaviors in a hollow fiber bundle of a commercial oxgenator using computational analysis method. A micro passage model is simulated arectangular part of a hollow fiber bundle. this computational model consists of parallel and staggerd arranged two hollow fiber membranes ^*(225 μm outer diameter and 165 μm inner diameter). Blood flows outside of hollow fobers in a direction of perpendicular to gas flow direction. Our computational analysis method deals coupled mass transfer and fluid dynamics including blood-gas reaction. In initial blood condition, partial oxygen pressure (PO₂), partial carbon dioxide pressure (PCO₂) and hemoglobin concentration (Hb) were set at 37.7 mmHg, 45.0 mmHg and 12.0 g/dL. In Initial gas condition, PO₂ and PCO₂ ere set at 713.0 mmHg and 0.0 mHg. In each results of PO₂ and PCO₂ distributions, maximaum values of PO₂ and minimum values of PCO₂ were demonstrated in the wake of a hollow fiber. Max PO₂ and min PCO₂ were 39.1 mmHg and 44.4 mmHg, 38.9 mmHg and 44.5 mmHg, and 38.7 mmHg and 44.6 mmHg at 1, 3, 5 L/min blood and gas flows, respectively.In conclusion, our computational analysis method is able to display distributions of PO₂ and PCO₂ in a micro passage among hollow fiber membranes.

Journal

• Journal of Life Support Engineering

  Journal of Life Support Engineering 21 (3), 124-129, 2009

  The Society of Life Support Engineering

Keywords

• Oxygenator
• Computational analysis
• Gas transfer
• Hollow fiber
• Blood-gas reaction

Details

• CRID: 1390001204368000000
• NII Article ID: 130002149607
• NII Article ID: 10029238038
• NII Book ID: AA11947931
• DOI: 10.5136/lifesupport.21.124
• ISSN: 18845827
• ISSN: 13419455
• Web Site: https://search.jamas.or.jp/link/ui/2010003032
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed