Usefulness of quantitative HBsAg in outcome prediction of acute hepatitis B

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  • Takahashi Hideaki
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, St. Marianna University, School of Medicine
  • Okuse Chiaki
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, St. Marianna University, School of Medicine
  • Yotsuyanagi Hiroshi
    Department of Internal Medicine, Division of Infectious Diseases, Faculty of Medicine, University of Tokyo
  • Yamada Norie
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, St. Marianna University, School of Medicine Department of Internal Medicine, Center for Liver Disease, Seizankai Kiyokawa Hospital
  • Yasuda Kiyomi
    Department of Internal Medicine, Center for Liver Disease, Seizankai Kiyokawa Hospital
  • Nagase Yoshihiko
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, St. Marianna University, School of Medicine
  • Suzuki Michihiro
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, St. Marianna University, School of Medicine
  • Koike Kazuhiko
    Department of Internal Medicine, Division of Gastroenterology, Faculty of Medicine, University of Tokyo
  • Itoh Fumio
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, St. Marianna University, School of Medicine

Bibliographic Information

Other Title
  • Ｂ型急性肝炎の経過予測におけるＨＢｓ抗原定量の有用性
  • Bガタ キュウセイ カンエン ノ ケイカ ヨソク ニ オケル HBs コウゲン テイリョウ ノ ユウヨウセイ

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Abstract

We evaluated the usefulness of quantitative evaluation of HBsAg in outcome prediction among 133 patients with acute hepatitis B (AH-B). Patients were classified into 4 groups according to duration of HBsAg positivity as follows: less than 3 months (Group I); less than 6 months (Group II); over 6 months (Group III); and over 12 months (Group IV). An abrupt decrease in HBsAg levels was observed and HBsAg levels at 2 weeks were significantly lower than those at the initial visit in Group I (p<0.001). On the other hand, levels of HBsAg remained high at 4 weeks and 8 weeks in Groups III and IV. Furthermore, HBsAg levels showed an increase from 2 weeks to 4 weeks in Group IV. These results suggest that quantitation of HBsAg at 4 or 8 weeks after initial visit may be useful in the prediction of clinical outcome in AH-B.<br>

Journal

  • Kanzo

    Kanzo 52 (6), 380-382, 2011

    The Japan Society of Hepatology

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