Sublethal Doses of Surfactants Induce Premature Senescence in Normal Human Skin Cells

• YAMAKAMI Yoshimi

  Department of Genome System Science, Yokohama City University

• MIKI Kensuke

  Department of Genome System Science, Yokohama City University

• ENDOH Morio

  Department of Genome System Science, Yokohama City University

• YONEKURA Ryuzo

  Department of Genome System Science, Yokohama City University

• UKEKAWA Ryo

  Department of Genome System Science, Yokohama City University

• KOBAYASHI Yusuke

  Department of Genome System Science, Yokohama City University

• FUJII Michihiko

  Department of Genome System Science, Yokohama City University

• AYUSAWA Dai

  Department of Genome System Science, Yokohama City University

Abstract

We evaluated the cytotoxicity of surfactants in human cells. Synthetic surfactants showed different cytotoxicity levels depending on their structures. The cytotoxicity of commercial washing products was determined mainly by the contents of surfactants. All of them induced premature senescence in normal cells, but not in tumor-derived or immortalized cells, under sublethal conditions. Residual surfactants might be a risk factor for skin aging.

Journal

• Bioscience, Biotechnology, and Biochemistry

  Bioscience, Biotechnology, and Biochemistry 75 (7), 1395-1398, 2011

  Japan Society for Bioscience, Biotechnology, and Agrochemistry

Keywords

• human cells
• cytotoxicity
• detergent
• cosmetics
• senescence

Details

• CRID: 1390282681453694848
• NII Article ID: 10029329611
• NII Book ID: AA10824164
• DOI: 10.1271/bbb.110179
• ISSN: 13476947
• ISSN: 09168451
• NDL BIB ID: 11175274
• PubMed: 21737914
• Web Site: http://id.ndl.go.jp/bib/11175274
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I11175274
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.110179
• Web Site: https://search.jamas.or.jp/link/ui/2011339600
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed