Validation of Automated Quantitation of Myocardial Perfusion and Fatty Acid Metabolism Abnormalities on SPECT Images

  • Yoshinaga Keiichiro
    Department of Photobiology, Division of Molecular, Cellular Imaging, Hokkaido University Graduate School of Medicine
  • Matsuki Takayuki
    Department of Cardiology, Shin-Nittetsu Muroran General Hospital
  • Hashimoto Akiyoshi
    Second Department of Internal Medicine, Sapporo Medical University
  • Tsukamoto Kazumasa
    Nihon Medi-Physics Co Ltd
  • Nakata Tomoaki
    Second Department of Internal Medicine, Sapporo Medical University Department of Cardiology, Hokkaido Prefectural Esashi Hospital
  • Tamaki Nagara
    Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine

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Background: Myocardial perfusion and fatty acid imaging have played important roles in the risk stratification of patients with coronary artery disease (CAD). However, visual image assessment requires considerable experience and training. Therefore, an automated program has been developed that can quantify perfusion and fatty acid uptake on myocardial single emission computed tomography (SPECT). The present study aimed to validate the automated quantitative program. Methods and Results: A total of 50 patients were studied with known or suspected CAD who underwent stress 201Thallium (201Tl) and resting 123I-labelled β-methyl iodophenyl pentadecanoic acid (BMIPP) SPECT. The SPECT images were quantified in 17 segments visually and using our Heart Score View software. Values were compared with those in a normal Japanese database and calculated summed stress (SSS), summed rest (SRS), summed difference (SDS), and summed BMIPP scores for each modality. Summed scores obtained using standard visual analysis and Heart Score View significantly correlated (201Tl: SSS: r=0.934; SRS: r=0.827; SDS: r=0.743 summed BMIPP score: r=0.913) (each P<0.001) and Bland-Altman analysis revealed good agreement between the 2 approaches. Conclusions: Correlations between scores determined using Heart Score View software and standard visual interpretation were linear for both perfusion and fatty acid images. Thus, our new automated program might be useful for the risk stratification of patients with CAD in the clinical setting. (Circ J 2011; 75: 2187-2195)<br>

収録刊行物

  • Circulation Journal

    Circulation Journal 75 (9), 2187-2195, 2011

    一般社団法人 日本循環器学会

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