Atherosclerosis Amelioration by Moderate Alcohol Consumption Is Associated With Increased Circulating Levels of Stromal Cell-Derived Factor-1

DOI Web Site PubMed 被引用文献3件 参考文献90件
  • Gil-Bernabe Paloma
    Department of Gastroenterology and Hepatology, Mie University Graduate School of Medicine
  • Boveda-Ruiz Daniel
    Department of Immunology, Mie University Graduate School of Medicine
  • D'Alessandro-Gabazza Corina
    Department of Gastroenterology and Hepatology, Mie University Graduate School of Medicine
  • Toda Masaaki
    Department of Immunology, Mie University Graduate School of Medicine
  • Miyake Yasushi
    Department of Immunology, Mie University Graduate School of Medicine
  • Mifuji-Moroka Rumi
    Department of Gastroenterology and Hepatology, Mie University Graduate School of Medicine
  • Iwasa Motoh
    Department of Gastroenterology and Hepatology, Mie University Graduate School of Medicine
  • Morser John
    Division of Hematology, Stanford University School of Medicine
  • Gabazza Esteban C.
    Department of Immunology, Mie University Graduate School of Medicine
  • Takei Yoshiyuki
    Department of Gastroenterology and Hepatology, Mie University Graduate School of Medicine

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Background: A moderate intake of alcohol is associated with lower cardiovascular mortality, and the role of circulating progenitor cells in the beneficial effect of alcohol on atherosclerosis is unclear. The hypothesis of this study was that alcohol ameliorates atherosclerosis by modulating the circulating levels of stromal cell-derived growth factor (SDF)-1 and vascular progenitor cells. Methods and Results: Atherosclerosis was induced by infusion of angiotensin II in apolipoprotein-E deficient mice, which were treated with high and low doses of ethanol for 28 days by intraperitoneal injection. Mice treated with low-dose ethanol had significantly less dilatation and fewer atheromatous lesions than mice receiving the high-dose ethanol. The number of circulating fibrocytes was significantly lower in mice treated with high-dose ethanol compared with mice with atherosclerosis untreated with ethanol. The plasma CXCL12/SDF-1 level was significantly increased in mice treated with low-dose ethanol compared with mice treated with a high dose, and the plasma concentration of transforming growth factor-β1 was significantly increased in mice treated with high-dose ethanol compared with control mice. Ethanol regulated the secretion of SDF-1 and vascular endothelial growth factor from fibroblasts in a dose-dependent and bimodal fashion. Conclusions: The circulating level of CXCL12/SDF-1 may be involved, at least in part, in the differential effects of alcohol consumption on atherosclerosis. (Circ J 2011; 75: 2269-2279)<br>

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  • Circulation Journal

    Circulation Journal 75 (9), 2269-2279, 2011

    一般社団法人 日本循環器学会

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