珪酸・アスベストの免疫影響  [in Japanese] Immunological Effects of Silica/Asbestos  [in Japanese]

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Author(s)

Abstract

Silica and asbestos cause pneumoconioses known as silicosis and asbestosis, respectively, that are each characterized by progressive pulmonary fibrosis. On the other hand, silicosis patients often suffer from a type of immunological dysregulation that gives rise to autoimmunity. These epidemiological findings suggest that silica may affect the immune system in humans. In addition, as asbestos itself is a mineral silicate, it may possess generalized immunotoxicological effects similar to those associated with silica particles. Because asbestos-exposed patients are well-known to often develop malignant diseases such as lung cancer and mesothelioma, one silica-like dysregulatory outcome that needs to be considered (apart from autoimmunity) is an alteration in host tumor immunity. In this review, the immunotoxicological effects of both silica and asbestos are presented and discussed in terms of immune system dysregulation as manifested by the onset of autoimmunity or alterations in host tumor immunity.<br>

Journal

  • Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene)

    Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene) 65(4), 493-499, 2010-09-15

    The Japanese Society for Hygiene

References:  64

Cited by:  1

Codes

  • NII Article ID (NAID)
    10029363262
  • NII NACSIS-CAT ID (NCID)
    AN00185923
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    00215082
  • NDL Article ID
    10844345
  • NDL Source Classification
    ZS17(科学技術--医学--衛生学・公衆衛生)
  • NDL Call No.
    Z19-194
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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