Remarkable Effect of a Modified Ketogenic Diet in a Boy with Focal Seizures Followed by Epileptic Spasms in a Cluster

DOI 12 References
  • Takahashi Hiroka
    National Epilepsy Center Shizuoka Institute of Epilepsy and Neurological Disorders
  • Imai Katsumi
    National Epilepsy Center Shizuoka Institute of Epilepsy and Neurological Disorders
  • Takayama Rumiko
    National Epilepsy Center Shizuoka Institute of Epilepsy and Neurological Disorders
  • Mine Jun
    National Epilepsy Center Shizuoka Institute of Epilepsy and Neurological Disorders
  • Ohtani Sanae
    National Epilepsy Center Shizuoka Institute of Epilepsy and Neurological Disorders
  • Ikeda Hiroko
    National Epilepsy Center Shizuoka Institute of Epilepsy and Neurological Disorders
  • Kubota Yuko
    National Epilepsy Center Shizuoka Institute of Epilepsy and Neurological Disorders
  • Takahashi Yukitoshi
    National Epilepsy Center Shizuoka Institute of Epilepsy and Neurological Disorders
  • Inoue Yushi
    National Epilepsy Center Shizuoka Institute of Epilepsy and Neurological Disorders
  • Fujiwara Tateki
    National Epilepsy Center Shizuoka Institute of Epilepsy and Neurological Disorders

Bibliographic Information

Other Title
  • 緩和ケトン食が著効した部分発作とスパズムの複合発作を有するてんかんの1男児例

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Abstract

  A modified ketogenic diet was demonstrated to be remarkably effective in a child with intractable symptomatic focal epilepsy with combined seizures of focal seizures and epileptic spasms (ES) in a cluster (ESC). ES started at 8 months of age and disappeared with ACTH therapy. At the age of 13 months, the child began to have intractable focal seizures that, later, were followed by ESC 10 times a day. Brain MRI showed only a non-specific diffuse cerebral atrophy. Interictal EEG showed high amplitude diffuse disorganized slow waves with prominent sharp waves predominant over the bilateral occipital region. We started a modified ketogenic diet (mKD) treatment without fasting or a water/calorie limitation. Since the 20th day of mKD, the patient has been seizure free (6 months) without adverse effects. EEG showed remarkable improvement and he has some improvement in the developmental milestones. A modified ketogenic diet is easier to start and continue compared to the classic ketogenic diet, and should be tried in intractable epilepsies that are not treatable surgically early in life from the developmental prognosis point of view.

Journal

  • NO TO HATTATSU

    NO TO HATTATSU 43 (4), 305-308, 2011

    The Japanese Society of Child Neurology

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