Cancer immunotherapy by utilizing dedritic cells derived from pluripotent stem cells.

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  • FUKUSHIMA Satoshi
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University Department of Immunogenetics, Faculty of Life Sciences, Kumamoto University
  • IHN Hironobu
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University
  • NISHIMURA Yasuharu
    Department of Immunogenetics, Faculty of Life Sciences, Kumamoto University
  • SENJU Satoru
    Department of Immunogenetics, Faculty of Life Sciences, Kumamoto University

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  • 多能性幹細胞から誘導した樹状細胞によるがん免疫療法

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Abstract

  It was recently revealed that ES-cell like pluripotent stem cells, designated as iPS cells, can be generated from somatic cells. iPS cells could be used as not only a source of regeneration medicine, but also a source of cell vaccine. Pluripotent stem cells are characterized by pluripotency and infinite propagation capacity. Non-virus-mediated methods for gene transfer have been established. Genetic modification of pluripotent stem cells and subsequent in vitro differentiation to dendritic cells would be an attractive strategy. Here we describe the previous studies about cancer immunotherapy by utilizing dendritic cells derived from pluripotent stem cells.<br>

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