Cellular compatibility of a gamma-irradiated modified siloxane-poly(lactic acid)-calcium carbonate hybrid membrane for guided bone regeneration

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Author(s)

    • TAKEUCHI Naoshi
    • Department of Periodontology, Graduate School of Medical and Dental Sciences, Kagoshima University
    • MACHIGASHIRA Miho
    • Department of Periodontology, Graduate School of Medical and Dental Sciences, Kagoshima University
    • YAMASHITA Daisuke
    • Department of Periodontology, Graduate School of Medical and Dental Sciences, Kagoshima University
    • SHIRAKATA Yoshinori
    • Department of Periodontology, Graduate School of Medical and Dental Sciences, Kagoshima University
    • KASUGA Toshihiro
    • Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology
    • NOGUCHI Kazuyuki
    • Department of Periodontology, Graduate School of Medical and Dental Sciences, Kagoshima University
    • BAN Seiji
    • Departments of Dental Materials Science, School of Dentistry, Aichi-Gakuin University

Abstract

A bi-layered silicon-releasable membrane consisting of a siloxane-poly(lactic acid) (PLA)-vaterite hybrid material (Si-PVH) microfiber mesh and a PLA microfiber mesh has been developed by an electrospinning method for guided bone regeneration (GBR) application. The bi-layered membrane was modified to a three-laminar structure by sandwiching an additional PLA microfiber mesh between the Si-PVH and PLA microfiber meshes (Si-PVH/PLA membrane). In this study, the influence of gamma irradiation, used for sterilization, on biological properties of the Si-PVH/PLA membrane was evaluated with osteoblasts and fibroblasts. After gamma irradiation, while the average molecular weight of the Si-PVH/PLA membrane decreased, the Si-PVH/PLA membrane promoted cell proliferation and differentiation (alkaline phosphatase activity and calcification) of osteoblasts, compared with the poly(lactide-co-glycolide) membrane. These results suggest that the gamma-irradiated Si-PVH/PLA membrane is biocompatible with both fibroblasts and osteoblasts, and may have an application for GBR.

Journal

  • Dental Materials Journal

    Dental Materials Journal 30(5), 730-738, 2011-09-01

    The Japanese Society for Dental Materials and Devices

References:  27

Codes

  • NII Article ID (NAID)
    10029480906
  • NII NACSIS-CAT ID (NCID)
    AA10443149
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    02874547
  • Data Source
    CJP  IR  J-STAGE 
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