Cellular compatibility of a gamma-irradiated modified siloxane-poly(lactic acid)-calcium carbonate hybrid membrane for guided bone regeneration
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- TAKEUCHI Naoshi
- Department of Periodontology, Graduate School of Medical and Dental Sciences, Kagoshima University
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- MACHIGASHIRA Miho
- Department of Periodontology, Graduate School of Medical and Dental Sciences, Kagoshima University
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- YAMASHITA Daisuke
- Department of Periodontology, Graduate School of Medical and Dental Sciences, Kagoshima University
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- SHIRAKATA Yoshinori
- Department of Periodontology, Graduate School of Medical and Dental Sciences, Kagoshima University
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- KASUGA Toshihiro
- Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology
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- NOGUCHI Kazuyuki
- Department of Periodontology, Graduate School of Medical and Dental Sciences, Kagoshima University
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- BAN Seiji
- Departments of Dental Materials Science, School of Dentistry, Aichi-Gakuin University
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Author(s)
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- TAKEUCHI Naoshi
- Department of Periodontology, Graduate School of Medical and Dental Sciences, Kagoshima University
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- MACHIGASHIRA Miho
- Department of Periodontology, Graduate School of Medical and Dental Sciences, Kagoshima University
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- YAMASHITA Daisuke
- Department of Periodontology, Graduate School of Medical and Dental Sciences, Kagoshima University
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- SHIRAKATA Yoshinori
- Department of Periodontology, Graduate School of Medical and Dental Sciences, Kagoshima University
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- KASUGA Toshihiro
- Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology
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- NOGUCHI Kazuyuki
- Department of Periodontology, Graduate School of Medical and Dental Sciences, Kagoshima University
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- BAN Seiji
- Departments of Dental Materials Science, School of Dentistry, Aichi-Gakuin University
Abstract
A bi-layered silicon-releasable membrane consisting of a siloxane-poly(lactic acid) (PLA)-vaterite hybrid material (Si-PVH) microfiber mesh and a PLA microfiber mesh has been developed by an electrospinning method for guided bone regeneration (GBR) application. The bi-layered membrane was modified to a three-laminar structure by sandwiching an additional PLA microfiber mesh between the Si-PVH and PLA microfiber meshes (Si-PVH/PLA membrane). In this study, the influence of gamma irradiation, used for sterilization, on biological properties of the Si-PVH/PLA membrane was evaluated with osteoblasts and fibroblasts. After gamma irradiation, while the average molecular weight of the Si-PVH/PLA membrane decreased, the Si-PVH/PLA membrane promoted cell proliferation and differentiation (alkaline phosphatase activity and calcification) of osteoblasts, compared with the poly(lactide-co-glycolide) membrane. These results suggest that the gamma-irradiated Si-PVH/PLA membrane is biocompatible with both fibroblasts and osteoblasts, and may have an application for GBR.
Journal
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- Dental Materials Journal
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Dental Materials Journal 30(5), 730-738, 2011-09-01
The Japanese Society for Dental Materials and Devices
References: 27
-
1
- Guided bone regeneration for dental implants
-
HERMANN JS
Curr Opin Periodontol 3, 168-177, 1996
Cited by (1)
-
2
- Vertical ridge augmentation using guided bone regeneration (GBR) in three clinical scenarios prior to implant placement : a retrospective study of 35 patients 12 to 72 months after loading
-
URBAN IA
Int J Oral Maxillofac Implants 24, 502-510, 2009
Cited by (1)
-
3
- Bone augmentation by means of barrier membranes
-
HAMMERLE CH
Periodontol 2000 33, 36-53, 2003
Cited by (1)
-
4
- Vertical ridge augmentation with guided bone regeneration in association with dental implants : an experimental study in dogs
-
SIMION M
Clin Oral Implants Res 18, 86-94, 2007
Cited by (1)
-
5
- A review of material properties of biodegradable and bioresorbable polymers and devices for GTR and GBR applications
-
HUTMACHER D
Int J Oral Maxillofac Implants 11, 667-678, 1996
Cited by (1)
-
6
- <no title>
-
HARDWICK R
Guided bone regeneration in implant dentistry, 101-137, 1994
Cited by (1)
-
7
- Zeolite A increases proliferation, differentiation, and transforming growth factor beta production in normal adult human osteoblast-like cells in vitro
-
KEETING PE
J Bone Miner Res 7, 1281-1289, 1992
Cited by (1)
-
8
- Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells in vitro
-
REFFITT DM
Bone 32, 127-135, 2003
Cited by (1)
-
9
- Electrospun microfiber meshes of silicon-doped vaterite/poly (lactic acid) hybrid for guided bone regeneration
-
OBATA A
Acta Biomater 6, 1248-1257, 2010
Cited by (1)
-
10
- gamma-irradiation of PEGd, lPLA and PEG-PLGA multiblock copolymers : II. effect of oxygen and EPR investigation
-
DORATI R
AAPS PharmSciTech 9, 1110-1118, 2008
Cited by (1)
-
11
- Cell-intercepting Ability of electrospun poly (lactic-acid)-based fibermats
-
FUJIKURA K
Bioceramics 22, 653-656, 2009
Cited by (1)
-
12
- Development of a 3D cell culture system for investigating cell interactions with electrospun fibers
-
SUN T
Biotechnol Bioeng 97, 1318-1328, 2007
Cited by (1)
-
13
- Preparation of electrospun siloxane-poly (lactic acid)-vaterite hybrid fibrous membranes for guided bone regeneration
-
WAKITA T
Compos Sci Technol 70, 1889-1893, 2010
Cited by (1)
-
14
- The effect of gamma radiation on molecular stability and mechanical properties of biodegradable polyurethanes for medical applications
-
GORNA K
Polym Degrad Stab 79, 465-474, 2003
Cited by (1)
-
15
- COMP-Ang1, a chimeric form of Angiopoietin 1, enhances BMP2-induced osteoblast differentiation and bone formation
-
JEONG BC
Bone 46, 479-486, 2010
Cited by (1)
-
16
- Effect of in vivo and in vitro degradation on molecular and mechanical properties of various low-molecular-weight polylactides
-
MAINIL-VARLET P
J Biomed Mater Res A 36, 360-380, 1997
Cited by (1)
-
17
- Enhanced in vitro cell activity on silicon-doped vaterite/poly (lactic acid) composites
-
OBATA A
Acta Biomater 5, 57-62, 2009
Cited by (1)
-
18
- Effect of (poly)-L-lactic acid on the proliferation and differentiation of primary bone cells in vitro
-
OTTO TE
J Biomed Mater Res 32, 513-518, 1996
Cited by (1)
-
19
- Silicon : A possible factor in bone calcification
-
CARLISLE E. M.
Science 167, 279-280, 1970
DOI Cited by (5)
-
20
- Differentiation of fetal osteoblasts and formation of mineralized bone nodules by 45S5 Bioglass conditioned medium in the absence of osteogenic supplements
-
TSIGKOU O
Biomaterials 30, 3542-3550, 2009
Cited by (1)
-
21
- <no title>
-
XYNOS I. D.
Biochem. Biophys. Res. Commun. 276, 461-465, 2000
DOI Cited by (12)
-
22
- Radiation effects on poly (lactic acid)
-
GUPTA M.
Polymer 24, 827-830, 1983
Cited by (1)
-
23
- Electrospun nanofibrous structure : a novel scaffold for tissue engineering
-
LI W
J Biomed Mater Res 60, 613-621, 2002
DOI Cited by (4)
-
24
- Effect of preparation route on the degradation behavior and ion releasability of siloxane-poly(lactic acid)-vaterite hybrid nonwoven fabrics for guided bone regeneration
-
WAKITA Takashi , NAKAMURA Jin , OTA Yoshio , OBATA Akiko , KASUGA Toshihiro , BAN Seiji
Dental Materials Journal 30(2), 232-238, 2011-03-01
IR J-STAGE Ichushi Web References (20) Cited by (1)
-
25
- Effects of calcium ion on cell growth, mineralized nodule formation and gene expression of extracellular matrix proteins of osteoblast-like cells [in Japanese]
-
ORII Hiromichi
日大歯学 73(5), 558-566, 1999-09-30
Ichushi Web References (32) Cited by (9)
-
26
- IGF-I mediates the stimulatory effect of high phosphate concentration on osteoblastic cell proliferation
-
KANATANI M
J Cell Physiol 190, 306-312, 2002
Cited by (1)
-
27
- Enhancing effect of poly (L-lactide) on the differentiation of mouse osteoblast-like MC3T3-E1 cells
-
ISAMA K.
Biomaterials 24, 3303-3309, 2003
Cited by (3)