Symptoms predicting pain relief with gabapentin in patients with neuropathic pain

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  • HIROSE Munetaka
    Department of Anesthesiology and Reanimatology, Faculty of Medical Sciences, University of Fukui
  • SAKAI Mikako
    Department of Anesthesiology and Reanimatology, Faculty of Medical Sciences, University of Fukui
  • MATSUKI Yuka
    Department of Anesthesiology and Reanimatology, Faculty of Medical Sciences, University of Fukui
  • TABATA Mari
    Department of Anesthesiology and Reanimatology, Faculty of Medical Sciences, University of Fukui
  • SEKI Kumiko
    Department of Anesthesiology and Reanimatology, Faculty of Medical Sciences, University of Fukui
  • SHIGEMI Kenji
    Department of Anesthesiology and Reanimatology, Faculty of Medical Sciences, University of Fukui

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Other Title
  • 神経障害性疼痛の症状から予測するガバペンチンの鎮痛効果
  • シンケイ ショウガイセイ トウツウ ノ ショウジョウ カラ ヨソク スル ガバペンチン ノ チンツウ コウカ

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Abstract

Aim: We attempted to clarify symptoms that could predict pain relief with gabapentin in patients with neuropathic pain.<br>Methods: We performed a logistic regression analysis in patients with various neuropathic pain disorders who took gabapentin in a retrospective cohort study (n=53). Thereafter, we studied to confirm the effectiveness of gabapentin for neuropathic pain in patients with or without the selected symptoms from the retrospective cohort study in a prospective cohort study (n=24).<br>Results: The retrospective cohort study showed the presence of allodynia and dysesthesia were significant positive and negative factors, respectively, of pain relief with gabapentin. The adjusted odds ratio was 11.43 (95% confidence interval, 1.87-70.06) for allodynia and 0.08 (95% confidence interval, 0.01-0.74) for dysesthesia. Thus, allodynia and dysesthesia were selected as factors to predict the effectiveness of gabapentin. The prospective cohort study, however, showed that there were no statistically significant factors predicting pain relief with gabapentin. Pain in patients without dysesthesia tended to decrease with gabapentin.<br>Conclusions: We conclude that pain may be relieved with gabapentin in patients without dysesthesia.

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