Bcl11b Heterozygosity Leads to Age-Related Hearing Loss and Degeneration of Outer Hair Cells of the Mouse Cochlea

• OKUMURA Hitoshi

  Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata University Department of Otorhinolaryngology, Graduate School of Medical and Dental Sciences, Niigata University

• MIYASAKA Yuki

  Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata University

• MORITA Yuka

  Department of Otorhinolaryngology, Graduate School of Medical and Dental Sciences, Niigata University

• NOMURA Tomoyuki

  Department of Otorhinolaryngology, Graduate School of Medical and Dental Sciences, Niigata University

• MISHIMA Yukio

  Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata University

• TAKAHASHI Sugata

  Department of Otorhinolaryngology, Graduate School of Medical and Dental Sciences, Niigata University

• KOMINAMI Ryo

  Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata University

抄録

BCL11B/CTIP2 zinc-finger transcription factor is expressed in various types of cells in many different tissues. This study showed that BCL11B is expressed in the nucleus of the outer hair cells of the mouse cochlea, degeneration of which is known to cause deafness and presbycusis or age-related hearing loss (AHL). We tested whether or not Bcl11b heterozygosity would affect AHL in mice. Analysis of auditory brainstem responses revealed AHL in Bcl11b^+/– heterozygous, but not wild-type, mice, which was evident as early as 3 months after birth. Histological abnormalities were observed in the outer hair cells of the Bcl11b ^+/– mice at 6 months of age with hearing loss. These results suggest that the AHL observed in Bcl11b^+/– mice is the result of impairment of the outer hair cells and that BCL11B activity is required for the maintenance of outer hair cells and normal hearing.<br>

収録刊行物

• Experimental Animals

  Experimental Animals 60 (4), 355-361, 2011

  公益社団法人 日本実験動物学会

キーワード

• BCL11B/CTIP2
• Corti organ
• hair cell
• hearing loss
• presbycusis

詳細情報

• CRID: 1390001205045352704
• NII論文ID: 10029550638
• NII書誌ID: AA11032321
• DOI: 10.1538/expanim.60.355
• ISSN: 18817122
• ISSN: 00075124
• ISSN: 13411357
• NDL書誌ID: 11143682
• PubMed: 21791875
• Web Site: http://id.ndl.go.jp/bib/11143682
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I11143682
• Web Site: http://www.jstage.jst.go.jp/article/expanim/60/4/60_4_355/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2012122895
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可