老化促進モデルマウスSAMP8における呼吸酵素複合体1活性低下はミトコンドリアDNAではなく核が原因である Nuclear but Not Mitochondrial DNA Involvement in Respiratory Complex I Defects Found in Senescence-Accelerated Mouse Strain, SAMP8

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Author(s)

Abstract

This study determined pathogenicity of an A11181G mtDNA mutation found in a senescence-accelerated mouse strain, SAMP8. The mutation was at a highly conserved site of the <i>mt-Nd4</i> gene, which encodes one of the respiratory complex I subunits. The young SAMP8 expressed reduced complex I activity, which is controlled by both nuclear and mitochondrial DNA (mtDNA). To exclude the nuclear effects, we isolated transmitochondrial cybrids that share the same nuclear background, but possess mtDNA with or without the mutation. The cybrids showed normal respiratory function irrespective of whether their mtDNA possessed the mutation or not, suggesting that the A11181G mutation is not responsible for respiration defects found in SAMP8.<br>

Journal

  • Experimental Animals

    Experimental Animals 60(4), 397-404, 2011-07-01

    Japanese Association for Laboratory Animal Science

References:  23

Codes

  • NII Article ID (NAID)
    10029550792
  • NII NACSIS-CAT ID (NCID)
    AA11032321
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    13411357
  • NDL Article ID
    11143795
  • NDL Source Classification
    ZS7(科学技術--医学)
  • NDL Call No.
    Z54-H752
  • Data Source
    CJP  NDL  IR  J-STAGE 
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