Association of the Common Fat Mass and Obesity Associated (FTO) Gene Polymorphism with Obesity in a Japanese Population

• KARASAWA Shigeru

  Third Department of Internal Medicine, Yamagata University Faculty of Medicine, Yamagata, Japan

• DAIMON Makoto

  Third Department of Internal Medicine, Yamagata University Faculty of Medicine, Yamagata, Japan Global Center of Excellence Program Study Group, Yamagata University School of Medicine, Yamagata, Japan

• SASAKI Satoshi

  Department of Social and Preventive Epidemiology, School of Public Health, the University of Tokyo, Tokyo, Japan

• TORIYAMA Sayumi

  Third Department of Internal Medicine, Yamagata University Faculty of Medicine, Yamagata, Japan HuBit Genomix Research Institute, Tokyo, Japan

• OIZUMI Toshihide

  Third Department of Internal Medicine, Yamagata University Faculty of Medicine, Yamagata, Japan

• SUSA Shinji

  Third Department of Internal Medicine, Yamagata University Faculty of Medicine, Yamagata, Japan

• KAMEDA Wataru

  Third Department of Internal Medicine, Yamagata University Faculty of Medicine, Yamagata, Japan

• WADA Kiriko

  Third Department of Internal Medicine, Yamagata University Faculty of Medicine, Yamagata, Japan

• MURAMATSU Masaaki

  HuBit Genomix Research Institute, Tokyo, Japan Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

• FUKAO Akira

  Global Center of Excellence Program Study Group, Yamagata University School of Medicine, Yamagata, Japan

• KUBOTA Isao

  Global Center of Excellence Program Study Group, Yamagata University School of Medicine, Yamagata, Japan

• KAWATA Sumio

  Global Center of Excellence Program Study Group, Yamagata University School of Medicine, Yamagata, Japan

• KAYAMA Takamasa

  Global Center of Excellence Program Study Group, Yamagata University School of Medicine, Yamagata, Japan

• KATO Takeo

  Third Department of Internal Medicine, Yamagata University Faculty of Medicine, Yamagata, Japan Global Center of Excellence Program Study Group, Yamagata University School of Medicine, Yamagata, Japan

抄録

The association of the FTO gene polymorphism, rs9939609, with obesity was examined using the population of the Takahata study (n (M/F): 2,639 (1,168 / 1,470); age: 63.0 ± 10.2 years), a Japanese community-based study. The effects of lifestyle-related factors, including nutritional intake and physical activities, on the association were also examined. Body mass index (BMI) was significantly associated with the FTO gene polymorphism (p<0.001). A case-control association study of the FTO gene polymorphism with obesity using multiple logistic regression analysis showed a significant association of the genotype AA (odds ratio, 1.53 [95% confidential interval, 1.04-2.24]) after adjustment for age and gender. Analysis to examine the differences in lifestyle-related factors among the genotype groups showed a significant difference in the energy expenditure for moderate to high-intensity physical activity (PA) (≥ 3.0 METs) (p=0.012) with a significant decrease toward the genotype AA (p=0.027). The effect of energy expenditure for moderate to high-intensity PA on the association of the polymorphism with obesity was then examined using study groups stratified based on the energy expenditure for moderate to high-intensity PA (Low-PA and High-PA). The BMI was significantly higher in the genotype AA in the Low-PA group (p=0.016) but not in the High-PA group (p=0.103). Furthermore, the genotype AA was significantly associated with obesity (odds ratio, 2.39 [95% confidential interval, 1.19-4.80]) in the Low-PA group but not in the High- PA group (p=0.650). The FTO gene, rs9939609, was associated with obesity, and the association was evident in subjects with low-PA, suggesting a PA-dependent association.

収録刊行物

• Endocrine Journal

  Endocrine Journal 57 (4), 293-301, 2010

  一般社団法人 日本内分泌学会

キーワード

• FTO gene polymorphism
• Gene environmental interaction
• Physical activity
• Nutritional intake
• Population-based study

詳細情報

• CRID: 1390282681276614528
• NII論文ID: 10029584254
• NII書誌ID: AA10901436
• DOI: 10.1507/endocrj.k09e-305
• ISSN: 13484540
• ISSN: 09188959
• Web Site: http://www.jstage.jst.go.jp/article/endocrj/57/4/57_K09E-305/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2010265525
• 本文言語コード: en
• データソース種別:
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  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可