The relationship between Receptor Activator of Nuclear Factor-.KAPPA.B Ligand (RANKL) gene polymorphism and aortic calcification in Korean women

DOI Web Site PubMed 被引用文献1件 参考文献62件
  • Rhee Eun-Jung
    Department of Endocrinology and Metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
  • Yun Eun-Joo
    Department of Radiology, Kangdong Sacred Heart Hospital, Hallym University, Seoul, Korea
  • Oh Ki-Won
    Department of Endocrinology and Metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
  • Park Se Eun
    Department of Endocrinology and Metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
  • Park Cheol-Young
    Department of Endocrinology and Metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
  • Lee Won-Young
    Department of Endocrinology and Metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
  • Park Sung-Woo
    Department of Endocrinology and Metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
  • Kim Sun-Woo
    Department of Endocrinology and Metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
  • Baek Ki-Hyun
    Department of Endocrinology and Metabolism, The Catholic University of Korea, College of Medicine, Seoul, Korea
  • Kang Moo Il
    Department of Endocrinology and Metabolism, The Catholic University of Korea, College of Medicine, Seoul, Korea

この論文をさがす

抄録

The aim of this study was to investigate the relationship between RANKL gene polymorphisms and aortic calcification in Korean women. In 237 healthy Korean women, aortic calcification in thoracic and abdominal aorta was examined in simple radiologic method and lumbar spine and femoral neck BMD were examined by dual energy X-ray absorptiometry. Serum OPG levels, bone turnover markers, such as ALP levels and urine deoxypyridinoline levels, and urine calcium excretion were measured. Genotyping of two RANKL gene polymorphisms, rs2277438 and rs9594782, was performed by allelic discrimination using the 5’ nuclease polymerase chain reaction assay. The subjects with CT/CC genotypes of the rs9594782 polymorphism had a 3.9 times higher risk of aortic calcification compared with TT genotype. This significance was significant even after adjustment for age, BMI, blood pressure, fasting plasma glucose, serum highand low-density lipoprotein cholesterol levels. Mean levels of urine deoxypyridinoline were significantly higher in the subjects with AG/GG genotypes of the rs2277438 polymorphism compared with AA genotype, and this significance was persistent even after adjustment for age and BMI. There were no associations of mean values for age, BMI, serum OPG and ALP levels, urine calcium excretion, and BMD with RANKL gene polymorphisms. The RANKL gene rs9594782 polymorphism was associated with aortic calcification in Korean women. Rs2277438 polymorphism showed significant association with urine deoxypyridinoline levels, a bone resorption marker. These results suggest its role on vascular calcification and bone metabolism in humans.

収録刊行物

  • Endocrine Journal

    Endocrine Journal 57 (6), 541-549, 2010

    一般社団法人 日本内分泌学会

被引用文献 (1)*注記

もっと見る

参考文献 (62)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ