Association of urine acidification with visceral obesity and the metabolic syndrome

• Otsuki Michio

  Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan

• Kitamura Tetsuhiro

  Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan

• Goya Kayoko

  Department of Medicine, Nissay Hospital, Osaka, Japan

• Saito Hiroshi

  Department of Internal Medicine, Kinki Central Hospital, Hyogo, Japan

• Mukai Mikio

  Department of Internal Medicine, Kinki Central Hospital, Hyogo, Japan

• Kasayama Soji

  Department of Medicine, Nissay Hospital, Osaka, Japan

• Shimomura Iichiro

  Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan

• Koga Masafumi

  Department of Internal Medicine, Kinki Central Hospital, Hyogo, Japan

抄録

Urine acidification is induced by metabolic acidosis which is associated with a high intake of protein-rich diet. The purpose of this study was to investigate the relationship of urine acidification with visceral obesity and the metabolic syndrome. We recruited 1,051 male subjects who underwent health examinations at the Health Care Center in Kinki Central Hospital. Subjects who were treated for hypertension, dyslipidemia, diabetes mellitus, and hyperuricemia and had the past history of chronic liver disease, chronic kidney disease and cancer, were excluded in this study. All subjects were administered to urine pH, blood and physical examinations. Lower urine pH was associated with higher serum urea nitrogen which reflects high intake of protein-rich diet, whereas it had no relation to serum creatinine. Lower urine pH was also associated with an increase in waist circumference, homeostasis model assessment-R, fasting plasma glucose, HbA1c, serum triglyceride, serum uric acid and with a decrease in high density lipoprotein cholesterol. Urine pH was not associated with mean blood pressure. Urine acidification is a characteristic of visceral obesity and the metabolic syndrome. High intake of protein-rich diet may contribute urine acidification, which is associated with various metabolic abnormalities in visceral obesity.

収録刊行物

• Endocrine Journal

  Endocrine Journal 58 (5), 363-367, 2011

  一般社団法人 日本内分泌学会

キーワード

• Urine acidification
• Metabolic acidosis
• Metabolic syndrome
• Hyperuricemia

詳細情報

• CRID: 1390001206298773632
• NII論文ID: 10029588604
• NII論文ID: 130004443696
• NII書誌ID: AA10901436
• DOI: 10.1507/endocrj.k10e-319
• ISSN: 13484540
• ISSN: 09188959
• Web Site: http://www.jstage.jst.go.jp/article/endocrj/58/5/58_K10E-319/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2012137259
• 本文言語コード: en
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