Identification of novel short peptide inhibitors of soluble 37/48 kDa oligomers of amyloid β42
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- KAWASAKI Takayasu
- Institute of Industrial Science, The University of Tokyo
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- ONODERA Kenji
- Institute of Industrial Science, The University of Tokyo
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- KAMIJO Shunsuke
- Institute of Industrial Science, The University of Tokyo
書誌事項
- タイトル別名
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- Identification of Novel Short Peptide Inhibitors of Soluble 37/48 kDa Oligomers of Amyloid .BETA.42
- Identification of novel short peptide inhibitors of soluble 37 48 kDa oligomers of amyloid v42
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抄録
Since the soluble oligomers of 42-residue amyloid β (Aβ42) might be neurotoxins at an early stage of Alzheimer’s disease (AD), inhibition of soluble Aβ42 oligomerization should be effective in the treatment of AD. We have found by phage display that a 7-residue peptide, SRPGLRR, exhibited inhibitory activity against soluble 37/48 kDa oligomers of Aβ42. In the present study, we newly prepared 3- and 4-residue random peptides libraries and performed pannings of them against soluble Aβ42 to search for important factors in the inhibition of Aβ42 oligomerization. After the fifth round, arginine-containing peptides were enriched in both libraries. SDS–PAGE and size-exclusion chromatography indicated that the inhibitory activities of 4-residue peptides against the soluble 37/48 kDa oligomers of Aβ42 were higher than those of the 3-residue peptides, and RFRK exhibited strong inhibitory activity as well as SRPGLRR. These short peptides should be useful for the suppression of soluble Aβ42 oligomer formation.
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 75 (8), 1496-1501, 2011
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390282681456494592
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- NII論文ID
- 10029591398
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- NII書誌ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 11222420
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- PubMed
- 21821948
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可