Achillinin A, a Cytotoxic Guaianolide from the Flower of Yarrow, Achillea millefolium

• LI Yong

  School of Basic Medicine, Hebei Medical University

• ZHANG Man-Li

  School of Pharmaceutical Sciences, Hebei Medical University

• CONG Bin

  School of Basic Medicine, Hebei Medical University

• WANG Si-Ming

  School of Pharmaceutical Sciences, Hebei Medical University

• DONG Mei

  School of Basic Medicine, Hebei Medical University

• SAURIOL Françoise

  Department of Chemistry, Queen’s University

• HUO Chang-Hong

  School of Pharmaceutical Sciences, Hebei Medical University

• SHI Qing-Wen

  School of Pharmaceutical Sciences, Hebei Medical University

• GU Yu-Cheng

  Syngenta Jealott’s Hill International Research Centre

• KIYOTA Hiromasa

  Graduate School of Agricultural Science, Tohoku University

Bibliographic Information

Other Title

• Achillinin A, a Cytotoxic Guaianolide from the Flower of Yarrow,<i>Achillea millefolium</i>

Abstract

Achillinin A (2β,3β-epoxy-1α,4β,10α-trihydroxyguai-11(13)-en-12,6α-olide, 1), a new guaianolide isolated from the flower of Achillea millefolium, exhibited potential antiproliferative activity to A549, RERF-LC-kj and QG-90 cells with 50% inhibitory concentration (IC₅₀) values of 5.8, 10 and 0.31 μM, respectively.

Journal

• Bioscience, Biotechnology, and Biochemistry

  Bioscience, Biotechnology, and Biochemistry 75 (8), 1554-1556, 2011

  Japan Society for Bioscience, Biotechnology, and Agrochemistry

Keywords

• <I>Achillea millefolium</I>
• flower
• guaianolide
• isolation

Details

• CRID: 1390282681456484480
• NII Article ID: 10029591671
• NII Book ID: AA10824164
• DOI: 10.1271/bbb.110234
• ISSN: 13476947
• ISSN: 09168451
• NDL BIB ID: 11222496
• PubMed: 21821943
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I11222496
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.110234
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed