Melanin Biosynthesis Inhibitors from Tarragon<i>Artemisia dracunculus</i>

• YAMADA Masayoshi

  FANCL Research Institute, FANCL Corporation

• NAKAMURA Kazuhiko

  Department of Chemistry, Kanagawa University

• WATABE Taeko

  Department of Chemistry, Kanagawa University

• OHNO Osamu

  Department of Biosciences and Informatics, Keio University

• KAWAGOSHI Masaru

  FANCL Research Institute, FANCL Corporation

• MARU Norihito

  Department of Chemistry, Kanagawa University

• UOTSU Nobuo

  FANCL Research Institute, FANCL Corporation

• CHIBA Tomohiro

  FANCL Research Institute, FANCL Corporation

• YAMAGUCHI Kohji

  FANCL Research Institute, FANCL Corporation

• UEMURA Daisuke

  FANCL Research Institute, FANCL Corporation

書誌事項

タイトル別名

• Melanin Biosynthesis Inhibitors from Tarragon Artemisia dracunculus

抄録

The EtOH extract of tarragon Artemisia dracunculus, a perennial herb in the family Asteraceae, was found to potently inhibit α-melanocyte-stimulating hormone (α-MSH) induced melanin production in B16 mouse melanoma cells. Bioassay-guided fractionation led to the isolation of two alkamide compounds, isobutyl (1) and piperidiyl (2) amides of undeca-2E,4E-dien-8,10-dynoic acid. The respective EC₅₀ values for melanin biosynthesis inhibition were 1.8 and 2.3 μg/mL for 1 and 2.

収録刊行物

• Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ

  Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 75 (8), 1628-1630, 2011

  公益社団法人 日本農芸化学会

キーワード

• melanin biosynthesis inhibitor
• skin-whitening
• alkamide
• α-melanocyte-stimulating hormone (α-MSH)

詳細情報

• CRID: 1390001206479883008
• NII論文ID: 10029592041
• NII書誌ID: AA10824164
• DOI: 10.1271/bbb.110306
• ISSN: 13476947
• ISSN: 09168451
• NDL書誌ID: 11222683
• PubMed: 21821921
• Web Site: http://id.ndl.go.jp/bib/11222683
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I11222683
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.110306
• Web Site: https://search.jamas.or.jp/link/ui/2012047299
• 本文言語コード: en
• データソース種別:
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  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
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