Polyphenols in Alcoholic Beverages Activating Constitutive Androstane Receptor CAR

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  • YAO Ruiqing
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
  • YASUOKA Akihito
    Department of Biological Engineering, Maebashi Institute of Technology
  • KAMEI Asuka
    Kanagawa Academy of Science and Technology
  • KITAGAWA Yoshinori
    Institute for Health Care Science, Suntory Wellness Ltd.
  • ROGI Tomohiro
    Institute for Health Care Science, Suntory Wellness Ltd.
  • TAIEISHI Norifumi
    Institute for Health Care Science, Suntory Wellness Ltd.
  • TSURUOKA Nobuo
    Institute for Health Care Science, Suntory Wellness Ltd.
  • KISO Yoshionobu
    Institute for Health Care Science, Suntory Wellness Ltd.
  • MISAKA Takumi
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
  • ABE Keiko
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo Kanagawa Academy of Science and Technology

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The constitutive androstane receptor CAR is a xenosensing nuclear receptor that can be activated by natural polyphenols such as flavonoids and catechins. We examined alcoholic beverage phytochemicals for their ability to activate CAR. HepG2 cells were transfected with CAR expression vector and its reporter gene, and then treated with trans-resveratrol, ellagic acid, β-caryophyllene, myrcene, and xanthohumol. A luciferase assay revealed that ellagic acid and trans-resveratrol activated both human and mouse CAR. Since CAR regulates many genes involved in energy metabolism, the possibility exists that these polyphenols would reduce the risk of certain alcohol-induced metabolic disorders with the help of CAR.

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