ハリクロリンの合成

• 樹林 千尋

  東京薬科大学薬学部

• 青柳 榮

  東京薬科大学薬学部

書誌事項

タイトル別名

• Synthesis of Halichlorine
• ハリクロリン ノ ゴウセイ

抄録

The naturally occurring marine alkaloid halichlorine, isolated from the black marine sponge Halichondria okadai Kadota, has been claimed to selectively inhibit the induced expression of vascular cell adhesion molecule-1 (VCAM-1) and might therefore be useful in the treatment of allergic inflammatory diseases and cancer. Stimulated by this intriguing biological profile, as well as the challenging architectural features of halichlorine, a significant amount of work related to the synthesis of this compound has been disclosed. Since the first total synthesis of halichlorine by the Danishefsky group, two other syntheses have been reported by Heathcock and more recently by Clive. The remainder of the many publications in this area have dealt very largely with construction of the azaspirocyclic core system and with formal synthesis reliant on the Danishefsky route.

収録刊行物

• 有機合成化学協会誌

  有機合成化学協会誌 69 (9), 1006-1019, 2011

  公益社団法人 有機合成化学協会

キーワード

• halichlorine
• marine alkaloid
• marine sponge
• inhibitor of VCAM-1
• total synthesis
• formal synthesis
• azaspiro[4.5]decane
• tricyclic spiroquinolizidine

詳細情報

• CRID: 1390001205339533312
• NII論文ID: 10029617998
• NII書誌ID: AN0024521X
• DOI: 10.5059/yukigoseikyokaishi.69.1006
• COI: 1:CAS:528:DC%2BC3MXhtFyltr%2FL
• ISSN: 18836526
• ISSN: 00379980
• NDL書誌ID: 11230351
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I11230351
• 本文言語コード: ja
• データソース種別:
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  • NDL
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