生命にはなぜ水が必要なのか : たんぱく質の機能と水和構造の相関 [in Japanese] Why is water indispensable for life? : relevance of protein hydration to function [in Japanese]
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- 中迫 雅由 NAKASAKO Masayoshi
- 慶應義塾大学 理工学部物理学科 Department of Physics, Faculty of Science and Technology, Keio University
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- 松岳 大輔 MATSUOKA Daisuke
- 慶應義塾大学 理工学部物理学科 Department of Physics, Faculty of Science and Technology, Keio University
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Author(s)
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- 中迫 雅由 NAKASAKO Masayoshi
- 慶應義塾大学 理工学部物理学科 Department of Physics, Faculty of Science and Technology, Keio University
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- 松岳 大輔 MATSUOKA Daisuke
- 慶應義塾大学 理工学部物理学科 Department of Physics, Faculty of Science and Technology, Keio University
Abstract
<p>水は生命を育む液体と考えられているが,なぜ水が生命に必要なのか? という素朴な問いに対して,物理や化学の言葉で答えることは依然難しい.我々は,生命現象の素過程を担っているたんぱく質分子がどのように水に溶解して運動するのかを探求することで,この問いに物理化学的視点から答えたいと考えている.本稿では,これまでの低温X線結晶構造解析,分子動力学計算や構造データベース解析などで得られたたんぱく質-水界面の水和構造に関する知見を紹介し,ナノメートルスケールでの水と生命現象の関わりについての理解の現状をまとめるとともに,今後のたんぱく質水和構造研究の展開を考えたい.</p>
<p>Water is believed to be the mother liquor or matrix of life. However, we still do not have a clear answer to why water is indispensable for life in terms of physics and chemistry. To answer this question, we have been investigating how protein molecules acting as molecular machines in the elementary processes of life are solvated and work in water. Here, we report our investigations on protein hydration through cryogenic X-ray crystallography and molecular dynamics simulation, and discuss the relevance of protein hydration to life viewed at the nanometer scale toward future research studies on protein hydration.</p>
Journal
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- Oyo Buturi
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Oyo Buturi 80(10), 903-907, 2011-10-10
The Japan Society of Applied Physics
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