生命にはなぜ水が必要なのか : たんぱく質の機能と水和構造の相関  [in Japanese] Why is water indispensable for life? : relevance of protein hydration to function  [in Japanese]

Access this Article

Search this Article

Author(s)

Abstract

<p>水は生命を育む液体と考えられているが，なぜ水が生命に必要なのか？　という素朴な問いに対して，物理や化学の言葉で答えることは依然難しい．我々は，生命現象の素過程を担っているたんぱく質分子がどのように水に溶解して運動するのかを探求することで，この問いに物理化学的視点から答えたいと考えている．本稿では，これまでの低温X線結晶構造解析，分子動力学計算や構造データベース解析などで得られたたんぱく質-水界面の水和構造に関する知見を紹介し，ナノメートルスケールでの水と生命現象の関わりについての理解の現状をまとめるとともに，今後のたんぱく質水和構造研究の展開を考えたい．</p>

<p>Water is believed to be the mother liquor or matrix of life. However, we still do not have a clear answer to why water is indispensable for life in terms of physics and chemistry. To answer this question, we have been investigating how protein molecules acting as molecular machines in the elementary processes of life are solvated and work in water. Here, we report our investigations on protein hydration through cryogenic X-ray crystallography and molecular dynamics simulation, and discuss the relevance of protein hydration to life viewed at the nanometer scale toward future research studies on protein hydration.</p>

Journal

  • Oyo Buturi

    Oyo Buturi 80(10), 903-907, 2011-10-10

    The Japan Society of Applied Physics

References:  22

  • <no title>

    EISENBERG D.

    The structure and properties of water, 1969

    Cited by (1)

  • <no title>

    FINNEY J.

    Philos. Trans. R. Soc. London B 359, 1145, 2004

    Cited by (1)

  • <no title>

    BRANDEN C. I.

    Introduction to Protein Structure, 1991

    Cited by (1)

  • <no title>

    RUPLEY J. A.

    Adv. Protein Chem. 41, 37, 1991

    Cited by (1)

  • <no title>

    CHEN S.-H.

    Proc. Natl. Acad. Sci. U.S.A. 103, 9012, 2006

    Cited by (1)

  • <no title>

    中迫雅由

    蛋白質の結晶化 267, 2005

    Cited by (1)

  • <no title>

    NAKASAKO M.

    Cell. Mol. Biol. 47, 767, 2001

    Cited by (1)

  • <no title>

    HIGO J.

    J. Comp. Chem. 23, 1323, 2002

    Cited by (1)

  • <no title>

    YOKOMIZO T.

    Chem. Phys. Lett. 401, 332, 2005

    Cited by (1)

  • <no title>

    YOKOMIZO T.

    Chem. Phys. Lett. s 410, 31, 2005

    Cited by (1)

  • <no title>

    GEFFREY G. A.

    Inclusion Compounds 135, 1984

    Cited by (1)

  • <no title>

    KUMASAKA T.

    J. Biol. Chem. 228, 37103, 2007

    Cited by (1)

  • <no title>

    NAKASAKO M.

    Biochemistry 38, 9887, 1999

    Cited by (1)

  • <no title>

    NAKASAKO M.

    Biophys. Chem. 95, 211, 2002

    Cited by (1)

  • <no title>

    NAKASAKO M.

    J. Mol. Biol. 381, 718, 2008

    Cited by (1)

  • <no title>

    NAKASAKO M.

    J. Mol. Biol. 351, 627, 2005

    Cited by (1)

  • <no title>

    ZHANG L.

    Proc. Natl. Acad. Sci. U.S.A. 104, 18461, 2007

    Cited by (1)

  • <no title>

    MATSUOKA D.

    J. Phys. Chem. B 113, 11274, 2009

    Cited by (1)

  • <no title>

    MATSUOKA D.

    J. Phys. Chem. B 114, 4652, 2010

    Cited by (1)

  • <no title>

    NAKASAKO M.

    Phil. Trans. Roy. Soc. London B 359, 1191-1206, 2004

    DOI  Cited by (2)

  • <no title>

    NAKASAKO M.

    J. Mol. Biol. 289, 547, 1999

    DOI  Cited by (2)

  • <no title>

    NAKASAKO M.

    Biochemistry 40, 3069-3079, 2001

    DOI  Cited by (3)

Codes

  • NII Article ID (NAID)
    10029623197
  • NII NACSIS-CAT ID (NCID)
    AN00026679
  • Text Lang
    JPN
  • Article Type
    REV
  • ISSN
    03698009
  • NDL Article ID
    11267778
  • NDL Source Classification
    ZM17(科学技術--科学技術一般--力学・応用力学)
  • NDL Call No.
    Z15-243
  • DOI
    10.11470/oubutsu.80.10_903
  • Data Source
    CJP  NDL  J-STAGE 
Page Top