A Patient with Bronchial Asthma in Whom Eosinophilic Bronchitis and Bronchiolitis Developed during Treatment

• Fukushima Yasutsugu

  Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine

• Kamiya Kuniyoshi

  Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine

• Tatewaki Masamitsu

  Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine

• Fukushima Fumiya

  Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine

• Hirata Hirokuni

  Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine

• Ishii Yoshiki

  Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine

• Fukuda Takeshi

  Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine

抄録

A 56-year-old woman was referred to our hospital because of dyspnea, wheezing, and a productive cough. Eight years before presentation, bronchial asthma was diagnosed and the patient received inhaled corticosteroids plus antiasthmatic agents (a long-acting inhaled β2-agonist, leukotriene modifiers, and theophylline). Chest radiography showed small diffuse nodular shadows, and a computed tomographic scan showed thickening of the bronchi and bronchioles, with diffuse centrilobular nodules in both lung fields. A blood test and microscopic examination of the bronchoalveolar fluid revealed marked eosinophilia. Transbronchial lung biopsy and transbronchial biopsy showed eosinophilic bronchitis and bronchiolitis. After treatment with oral prednisolone (40mg daily) and inhaled corticosteroids, the symptoms, blood eosinophilia, and radiographic findings improved. Recently, several similar cases of eosinophilic bronchiolitis have been reported. Studies of further cases and elucidation of the pathophysiology of eosinophilic bronchiolitis are necessary to establish a concept for this disease and to determine whether it should be classified as a subtype of bronchial asthma or as a distinct entity.<br>

収録刊行物

• Allergology International

  Allergology International 59 (1), 87-91, 2010

  一般社団法人日本アレルギー学会

キーワード

• bronchial asthma
• bronchiolitis
• eosinophilic bronchiolitis
• eosinophilic lung disease

詳細情報

• CRID: 1390001204632971264
• NII論文ID: 10029669667
• NII論文ID: 130004477074
• NII書誌ID: AA11091750
• DOI: 10.2332/allergolint.09-cr-0114
• ISSN: 14401592
• ISSN: 13238930
• PubMed: 19946200
• Web Site: http://api.elsevier.com/content/article/PII:S1323893015305803?httpAccept=text/xml
• Web Site: http://api.elsevier.com/content/article/PII:S1323893015305803?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/2010264703
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可