The Malarial Metabolite Hemozoin and Its Potential Use as a Vaccine Adjuvant

• Coban Cevayir

  Laboratory of Host Defense, Immunology Frontier Research Center, World Premier Institute for Immunology, Osaka University Laboratory of Malaria Immunology, Immunology Frontier Research Center, World Premier Institute for Immunology, Osaka University

• Yagi Masanori

  Department of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka University

• Ohata Keiichi

  Laboratory of Host Defense, Immunology Frontier Research Center, World Premier Institute for Immunology, Osaka University ZENOAQ, Nippon Zenyaku Kogyo Co. Ltd.

• Igari Yoshikatsu

  ZENOAQ, Nippon Zenyaku Kogyo Co. Ltd.

• Tsukui Toshihiro

  ZENOAQ, Nippon Zenyaku Kogyo Co. Ltd.

• Horii Toshihiro

  Department of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka University

• Ishii Ken J

  Laboratory of Host Defense, Immunology Frontier Research Center, World Premier Institute for Immunology, Osaka University Department of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka University

• Akira Shizuo

  Laboratory of Host Defense, Immunology Frontier Research Center, World Premier Institute for Immunology, Osaka University

Abstract

Hemozoin, a bio-crystalline substance, is a hemin detoxification by-product of malaria parasites. The role of hemozoin crystals in host immune system modulation by malaria parasites, and how they interact with the immune system has been enigmatic. Here, we summarize recent progress in our understanding of how hemozoin might be interacting with the host immune system. In particular, the potential application of hemozoin crystals as an adjuvant may provide insights into the molecular mechanisms involved in immune responses to malarial infection and provide a rationale for the design of vaccines against malaria as well as other immunological disorders such as allergies.<br>

Journal

• Allergology International

  Allergology International 59 (2), 115-124, 2010

  Japanese Society of Allergology

Keywords

• adjuvant
• allergy
• hemozoin
• innate and adaptive immunity
• malaria
• NLRP3
• TLR9

Details

• CRID: 1390282679609378304
• NII Article ID: 10029669847
• NII Article ID: 130004477077
• NII Book ID: AA11091750
• DOI: 10.2332/allergolint.10-rai-0194
• ISSN: 14401592
• ISSN: 13238930
• PubMed: 20414048
• Web Site: http://api.elsevier.com/content/article/PII:S1323893015305839?httpAccept=text/xml
• Web Site: http://api.elsevier.com/content/article/PII:S1323893015305839?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/2010281822
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed